Kim Sungjune, Lalani Saif, Parekh Vrajesh V, Wu Lan, Van Kaer Luc
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Medical Center North, Nashville, TN 37232, USA.
Expert Rev Vaccines. 2008 Dec;7(10):1519-32. doi: 10.1586/14760584.7.10.1519.
Invariant natural killer T (iNKT) cells are a unique subset of T lymphocytes that recognize glycolipid antigens in the context of the antigen-presenting molecule CD1d. Upon glycolipid antigen stimulation, iNKT cells rapidly produce copious amounts of immunomodulatory cytokines, leading to potent activation of a variety of innate and adaptive immune cells. These immune-potentiating properties of iNKT cells hold great promise for the development of vaccine adjuvants. This review aims to summarize the immunomodulatory activities of iNKT cell ligands and to discuss prospects for developing iNKT cell-based vaccine adjuvants.
不变自然杀伤T（iNKT）细胞是T淋巴细胞的一个独特亚群，它们在抗原呈递分子CD1d的背景下识别糖脂抗原。在糖脂抗原刺激下，iNKT细胞迅速产生大量免疫调节细胞因子，从而有力地激活各种先天性和适应性免疫细胞。iNKT细胞的这些免疫增强特性为疫苗佐剂的开发带来了巨大希望。本综述旨在总结iNKT细胞配体的免疫调节活性，并讨论基于iNKT细胞的疫苗佐剂的开发前景。
