效应器和调节性 B 细胞：CD4+ T 细胞免疫的调节剂。
Effector and regulatory B cells: modulators of CD4+ T cell immunity.
机构信息
Department of Medicine, University of Rochester Medical Center, New York 14642, USA.
出版信息
Nat Rev Immunol. 2010 Apr;10(4):236-47. doi: 10.1038/nri2729. Epub 2010 Mar 12.
Abstract
B cells are essential for humoral immunity, but the role that they have in regulating CD4(+) T cell responses remains controversial. However, new data showing that the transient depletion of B cells potently influences the induction, maintenance and reactivation of CD4(+) T cells, with the recent identification of antibody-independent functions of B cells, have reinvigorated interest in the many roles of B cells in both infectious and autoimmune diseases. In this Review, we discuss recent data showing how effector and regulatory B cells modulate CD4(+) T cell responses to pathogens and autoantigens.
摘要
B 细胞对于体液免疫至关重要，但其在调控 CD4(+)T 细胞应答方面的作用仍存在争议。然而，新的数据表明，B 细胞的短暂耗竭会强烈影响 CD4(+)T 细胞的诱导、维持和再激活，最近发现了 B 细胞的抗体非依赖性功能，这重新激发了人们对 B 细胞在感染性和自身免疫性疾病中多种作用的兴趣。在这篇综述中，我们讨论了最近的数据，这些数据表明效应 B 细胞和调节性 B 细胞如何调节 CD4(+)T 细胞对病原体和自身抗原的应答。
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