慢性肾脏病的基本处理方法。

A basic approach to CKD.

机构信息

Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA.

出版信息

Kidney Int. 2010 Apr;77(7):567-9. doi: 10.1038/ki.2009.516.

DOI:10.1038/ki.2009.516

PMID:20224583

Abstract

Metabolic acidosis often complicates chronic kidney disease (CKD) and adversely affects bone, nutrition, and metabolism. Phisitkul et al. demonstrate that sodium citrate may ameliorate kidney injury in CKD patients not on dialysis. Further, they provide evidence in humans that treatment lowers urinary endothelin levels, and hence increased endothelin may be part of the mechanism whereby acidosis hastens CKD progression.

摘要

代谢性酸中毒常使慢性肾脏病（CKD）复杂化，并对骨骼、营养和代谢产生不利影响。Phisitkul 等人证明，柠檬酸鈉可改善未进行透析的 CKD 患者的肾脏损伤。此外，他们在人类中提供的证据表明，该治疗方法降低了尿内皮素水平，因此，内皮素增加可能是酸中毒加速 CKD 进展的机制之一。