Laws A, Stefanick M L, Reaven G M
Department of Medicine, Stanford University School of Medicine, Palo Alto, California.
J Clin Endocrinol Metab. 1989 Aug;69(2):343-7. doi: 10.1210/jcem-69-2-343.
Plasma glucose, FFA, and insulin responses to an oral glucose challenge, plasma lipid and lipoprotein concentrations, and the ability of insulin to stimulate glucose disposal were measured in 35 nondiabetic sedentary and overweight subjects. The subjects were divided into 2 groups on the basis of the presence (n = 19) or absence (n = 16) of a history of a first degree relative with noninsulin-dependent diabetes. The 2 groups were similar in age, body mass index, waist to hip ratio, and maximal aerobic capacity. The results demonstrated that the ability of insulin to stimulate disposal of a glucose load was significantly reduced in the subjects with a positive family history of noninsulin-dependent diabetes. In addition, these individuals had significantly higher plasma triglyceride and very low density lipoprotein cholesterol concentrations. Since all environmental factors known to modify insulin action and very low density lipoprotein metabolism were equal in the 2 groups, these data suggest that the metabolic differences noted are likely to be genetic in origin.
对35名非糖尿病久坐且超重的受试者测量了口服葡萄糖耐量试验后的血浆葡萄糖、游离脂肪酸和胰岛素反应、血浆脂质和脂蛋白浓度，以及胰岛素刺激葡萄糖清除的能力。根据是否有非胰岛素依赖型糖尿病一级亲属病史，将受试者分为两组（有病史组n = 19，无病史组n = 16）。两组在年龄、体重指数、腰臀比和最大有氧能力方面相似。结果表明，有非胰岛素依赖型糖尿病家族史阳性的受试者中，胰岛素刺激葡萄糖负荷清除的能力显著降低。此外，这些个体的血浆甘油三酯和极低密度脂蛋白胆固醇浓度显著更高。由于已知的所有影响胰岛素作用和极低密度脂蛋白代谢的环境因素在两组中均相同，这些数据表明所观察到的代谢差异可能源于遗传。
