Mubiru James N, Garcia-Forey Magdalena, Higgins Paul B, Hemmat Peggah, Cavazos Nicole E, Dick Edward J, Owston Michael A, Bauer Cassondra A, Shade Robert E, Comuzzie Anthony G, Rogers Jeffrey
Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
J Med Primatol. 2011 Oct;40(5):335-41. doi: 10.1111/j.1600-0684.2011.00495.x. Epub 2011 Aug 3.
The metabolic syndrome is common in populations exposed to a typical Western diet. There is a lack of an animal model that mimics this condition.
We fed 15 cynomolgus monkeys ad libitum a high-sugar high-fat (HSHF) diet for 33 weeks. Body weight, body composition, serum lipids, and insulin were measured at baseline and at 33 weeks.
The animals tolerated the HSHF diet very well. In the intervention group, total serum cholesterol and low-density lipoprotein cholesterol were 3- and 5-fold higher, respectively, at 33 weeks as compared with their baseline levels. Serum high-density lipoprotein cholesterol and triglycerides were not significantly affected. Dual-energy X-ray absorptiometry (DXA) analysis of the intervention group indicated that the trunk fat mass increased by 187% during this period.
Cynomolgus monkeys should be a useful model for investigating the interactions of diet and other factors such as genetics in the development of the metabolic syndrome.
代谢综合征在食用典型西方饮食的人群中很常见。目前缺乏模拟这种情况的动物模型。
我们给15只食蟹猴随意喂食高糖高脂（HSHF）饮食33周。在基线和33周时测量体重、身体成分、血脂和胰岛素。
这些动物对HSHF饮食耐受性良好。在干预组中，33周时血清总胆固醇和低密度脂蛋白胆固醇分别比基线水平高出3倍和5倍。血清高密度脂蛋白胆固醇和甘油三酯未受到显著影响。干预组的双能X线吸收法（DXA）分析表明，在此期间躯干脂肪量增加了187%。
食蟹猴应该是研究饮食与其他因素（如遗传学）在代谢综合征发展过程中相互作用的有用模型。
