Sepehrvand Nariman, Khameneh Zakieh Rostamzadeh, Eslamloo Hamid-Reza Farrokh
Department of Microbiology, Urmia University of Medical Sciences, Urmia, Iran.
Saudi J Kidney Dis Transpl. 2010 Mar;21(2):363-7.
Cytomegalovirus (CMV) causes infection in immunocompromised, transplant recipients and those who received blood transfusion frequently. Risk factors for primary CMV infection are blood transfusion (including clotting factors, etc), recipients of infected transplants, hemo-dialysis and the frequency of dialysis in a week. This study aimed at determining the prevalence of cytomegalovirus (CMV) antibodies in end-stage renal disease (ESRD) patients who undergo hemodialysis. A cross-sectional study of hemodialysis patients in Urmia, Iran was undertaken in 2007. Sera of 84 Hemodialysis patients were investigated for CMV-specific immunoglobulin G (IgG). Forty-four (52%) patients were males. 65 patients (77.4%) were anti-CMV IgG positive and 6 (7.1%) were anti-CMV IgM positive. There was no relationship between the antibody titer and dialysis duration, or frequency of HD in a week. In conclusion, we recommend that every patient who has undergone hemodialysis receive blood products free of CMV if CMV negative to reduce the incidence and prevalence of CMV among HD patients.
巨细胞病毒（CMV）可导致免疫功能低下者、移植受者以及频繁接受输血者感染。原发性CMV感染的危险因素包括输血（包括凝血因子等）、感染性移植受者、血液透析以及每周的透析频率。本研究旨在确定接受血液透析的终末期肾病（ESRD）患者中巨细胞病毒（CMV）抗体的流行情况。2007年在伊朗乌尔米耶对血液透析患者进行了一项横断面研究。对84例血液透析患者的血清进行了CMV特异性免疫球蛋白G（IgG）检测。44例（52%）患者为男性。65例（77.4%）患者抗CMV IgG阳性，6例（7.1%）患者抗CMV IgM阳性。抗体滴度与透析时间或每周血液透析频率之间无关联。总之，我们建议每一位接受过血液透析的患者，如果CMV阴性，应接受无CMV的血液制品，以降低血液透析患者中CMV的发病率和流行率。
