Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Immune Netw. 2010 Feb;10(1):1-4. doi: 10.4110/in.2010.10.1.1. Epub 2010 Feb 28.
Asthma is characterized by chronic airway inflammation with intense eosinophil and lymphocyte infiltration, mucus hyperproduction, and airway hyperresponsiveness. Accumulating evidence indicates that antigen-specific Th2 cells and their cytokines such as IL-4, IL-5, and IL-13 orchestrate these pathognomonic features of asthma. In addition, we and others have recently shown that IL-17-producing CD4(+) T cells (Th17 cells) and IL-23, an IL-12-related cytokine that is essential for survival and functional maturation of Th17 cells, are involved in antigen-induced airway inflammation. In this review, our current understanding of the roles of IL-23 and Th17 cells in the pathogenesis of allergic airway inflammation will be summarized.
哮喘的特征是慢性气道炎症，伴有强烈的嗜酸性粒细胞和淋巴细胞浸润、黏液高分泌和气道高反应性。越来越多的证据表明，抗原特异性 Th2 细胞及其细胞因子，如 IL-4、IL-5 和 IL-13，协调哮喘的这些特征性特征。此外，我们和其他人最近还表明，产生 IL-17 的 CD4(+) T 细胞（Th17 细胞）和 IL-23，一种与 IL-12 相关的细胞因子，对于 Th17 细胞的存活和功能成熟至关重要，参与了抗原诱导的气道炎症。在这篇综述中，我们将总结目前对 IL-23 和 Th17 细胞在过敏性气道炎症发病机制中的作用的理解。
