Hur Jae H, Cho Jaehyoung, Walker David W
Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Aging (Albany NY). 2010 Jan 26;2(1):69-73. doi: 10.18632/aging.100118.
A major goal of aging research is to identify interventions that prolong lifespan in distantly related organisms. In recent years, genetic studies in both nematodes and rodents have reported that moderate inactivation of genes important for mitochondrial electron transport chain (ETC) function can promote longevity. We performed an RNAi screen to probe the role of ETC components in modulating lifespan in the fruit fly Drosophila melanogaster. In this Research Perspective, we discuss our findings and how they may relate to similar studies in worms and mice.
衰老研究的一个主要目标是确定能延长远缘生物寿命的干预措施。近年来，对线虫和啮齿动物的基因研究表明，对线粒体电子传递链（ETC）功能重要的基因进行适度失活可延长寿命。我们进行了一项RNA干扰筛选，以探究ETC成分在调节果蝇寿命中的作用。在这篇“研究视角”文章中，我们讨论了我们的发现以及它们与在蠕虫和小鼠中进行的类似研究可能存在的关联。
