Institut für Organische Chemie der RWTH Aachen University, Landoltweg 1, 52056 Aachen (Germany), Fax: (+49) 241-8092391.
Chemistry. 2010 Apr 19;16(15):4577-87. doi: 10.1002/chem.200903077. Epub 2010 Mar 12.
Vinylogous Mukaiyama-type aldol reactions have been catalyzed by a combination of Cu(OTf)2 and readily available C1-symmetric aminosulfoximines. After a fine-tuning of the reaction conditions and an optimization of the modularly assembled ligand structure, high stereoselectivities and excellent yields have been achieved in catalyzed reactions involving various electrophile/nucleophile combinations. The relative and absolute configurations of two products were assigned by X-ray single crystal structure analysis and a comparison of calculated and experimental CD spectra.
通过 Cu(OTf)2 和易得的 C1 对称的氨基磺酰亚胺的组合，实现了 Vinylogous Mukaiyama-type 羟醛缩合反应的催化。经过对反应条件的精细调整和模块化组装配体结构的优化，在涉及各种亲电体/亲核体组合的催化反应中，实现了高立体选择性和优异的产率。通过 X 射线单晶结构分析和计算与实验 CD 光谱的比较，确定了两个产物的相对和绝对构型。
