铜催化的烯醇式 Mukaiyama 醛醇反应对高官能化酰胺的对映选择性合成。
Enantioselective synthesis of highly functionalised amides by copper-catalysed vinylogous Mukaiyama aldol reaction.
机构信息
Institute of Organic Chemistry RWTH Aachen University, Landoltweg 1, 52056 Aachen, Germany.
出版信息
Chem Commun (Camb). 2010 Aug 14;46(30):5497-9. doi: 10.1039/c0cc00996b. Epub 2010 Jun 24.
PMID:20574579
Abstract
Amides with quaternary stereogenic centers have been synthesised by catalytic asymmetric vinylogous Mukaiyama aldol reactions. The chiral copper-sulfoximine catalyst gives rise to products with moderate to good yields and up to 92% ee.
摘要
具有季立体中心的酰胺已通过催化不对称乙烯基 Mukaiyama 羟醛反应合成。手性铜-亚砜亚胺催化剂可得到中等至良好收率和高达 92%ee 的产物。
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