West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China.
DNA Cell Biol. 2010 Jun;29(6):319-23. doi: 10.1089/dna.2009.0960.
Genetic factors are known to be important in the development of gastric cancer (GC). Prostate stem cell antigen (PSCA) has been shown to be expressed in diffuse-type GC, and PSCA variation is associated with susceptibility to diffuse-type GC in Japanese and Korean populations. The aim of this study was to investigate the association between PSCA gene polymorphisms and GC in a Tibetan population. We analyzed single-nucleotide polymorphisms of the PSCA gene in 196 patients with GC and 246 controls in a Tibetan population, using a polymerase chain reaction/ligase detection reaction test. The rs2294008 C/T polymorphism of the PSCA gene was significantly associated with the susceptibility to GC. The CT genotype was associated with a significantly higher risk of GC when compared with the CC genotype (odds ratio [OR] = 1.50; 95% confidence interval [CI], 1.01-2.23). Patients carrying the T allele had a significantly higher risk for developing GC compared with individuals carrying the C allele (OR = 1.34; 95% CI, 1.00-1.79). Haplotype analyses showed that CA haplotype was associated with a significantly decreased risk of GC when compared with the CG haplotype (OR = 0.47; 95% CI, 0.24-0.93). Our data indicate that PSCA gene polymorphisms may be associated with GC in Tibetans.
遗传因素被认为在胃癌（GC）的发生中起重要作用。前列腺干细胞抗原（PSCA）已被证明在弥漫型 GC 中表达，PSCA 变异与日本和韩国人群弥漫型 GC 的易感性有关。本研究旨在探讨 PSCA 基因多态性与藏族人群 GC 的关系。我们使用聚合酶链反应/连接酶检测反应试验，分析了 196 例 GC 患者和 246 例藏族对照人群中 PSCA 基因的单核苷酸多态性。PSCA 基因的 rs2294008 C/T 多态性与 GC 的易感性显著相关。与 CC 基因型相比，CT 基因型与 GC 的发病风险显著增加（比值比[OR] = 1.50；95%置信区间[CI]，1.01-2.23）。与携带 C 等位基因的个体相比，携带 T 等位基因的患者发生 GC 的风险显著增加（OR = 1.34；95%CI，1.00-1.79）。单体型分析显示，与 CG 单体型相比，CA 单体型与 GC 的发病风险显著降低（OR = 0.47；95%CI，0.24-0.93）。我们的数据表明，PSCA 基因多态性可能与藏族人群的 GC 有关。
