Qiu Li-Xin, Cheng Lei, He Jing, Zhou Zhi-Rui, Wang Meng-Yun, Zhou Fei, Guo Wei-Jian, Li Jin, Sun Meng-Hong, Zhou Xiao-Yan, Wang Ya-Nong, Yang Ya-Jun, Wang Jiu-Cun, Jin Li, Zhu Xiao-Dong, Wei Qing-Yi
Department of Medical Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Cancer Institute, Collaborative Innovation Center for Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai, China.
Oncotarget. 2016 Feb 23;7(8):9420-8. doi: 10.18632/oncotarget.7137.
The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen (PSA), was identified as a gene involved in cell adhesion and proliferation. The associations between the PSCA rs2294008 and rs2976392 single nucleotide polymorphisms (SNPs) and gastric cancer (GCa) susceptibility were still controversial. To derive a more precise estimation of the associations, we conducted a case-control study of 1,124 cases and 1,192 controls in an eastern Chinese population. We found that the rs2294008T variant genotypes were associated with an increased GCa risk in this study population (CT vs CC, OR=1.59, 95% CI=1.33-1.89 and CT+TT vs CC, OR=1.38, 95% CI=1.17-1.62). For SNP rs2976392, the variant A genotypes were also associated with an increased GCa risk (AG vs GG, OR=1.61, 95% CI=1.35-1.91 and AG+AA vs GG, OR=1.47, 95% CI=1.25-1.74). The results were further validated by a meta-analysis. In conclusion, the results indicated that the PSCA rs2294008 T and rs2976392 A alleles were low-penetrate risk factors for GCa in this study population. However, large and well-designed studies are warranted to validate our findings.
前列腺干细胞抗原（PSCA）基因编码一种前列腺特异性抗原（PSA），该基因被确定为参与细胞黏附和增殖的基因。PSCA基因的rs2294008和rs2976392单核苷酸多态性（SNP）与胃癌（GCa）易感性之间的关联仍存在争议。为了更精确地评估这种关联，我们在中国东部人群中对1124例病例和1192例对照进行了一项病例对照研究。我们发现，在本研究人群中，rs2294008T变异基因型与GCa风险增加相关（CT与CC相比，OR = 1.59，95%CI = 1.33 - 1.89；CT + TT与CC相比，OR = 1.38，95%CI = 1.17 - 1.62）。对于SNP rs2976392，变异A基因型也与GCa风险增加相关（AG与GG相比，OR = 1.61，95%CI = 1.35 - 1.91；AG + AA与GG相比，OR = 1.47，95%CI = 1.25 - 1.74）。这些结果通过荟萃分析得到了进一步验证。总之，结果表明，在本研究人群中，PSCA rs2294008 T和rs2976392 A等位基因是GCa的低 penetrance风险因素。然而，需要大规模且设计良好的研究来验证我们的发现。
