Qin Zhiqiang, Tang Jingyuan, Li Xiao, Yu Yajie, Zhang Chuanjie, Han Peng, Li Ran, Jiang Xuping, Yang Chengdi, Wang Wei, Tang Min, Zhang Wei
Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Department of Urology, Wuxi Second People's Hospital, Nanjing Medical University, Wuxi, 214002, China.
Oncotarget. 2017 Apr 10;8(31):51766-51778. doi: 10.18632/oncotarget.17011. eCollection 2017 Aug 1.
Previous studies have investigated the relationships between PSCA rs2294008 C>T and rs2976392 G>A polymorphisms and cancer susceptibility. However, the available findings remained inconsistent and even controversial. Thus, the aim of this meta-analysis was performed to clarify such associations. The online databases PubMed, EMBASE and Web of Science searched for relevant studies, covering all the papers published until September 1st, 2016. Data were pooled by odds ratios (ORs) with 95% confidence intervals (CIs) to evaluate the strength of such associations. Then, trial sequential analysis was performed to estimate whether the evidence of the results was firm. Overall, a significant increased risk of cancer was associated with PSCA rs2294008 C>T and rs2976392 G>A polymorphisms. For the PSCA rs2294008 polymorphism, when stratified by type of cancer, the results were significant especially in gastric cancer and bladder cancer. Moreover, in the subgroup analysis by ethnicity, significant results were detected in both Asian and Caucasian populations. Similarly, for the PSCA rs2976392 polymorphism, the stratification analyses by type of cancer showed that the results were significant only in gastric cancer. In addition, the stratification analyses by ethnicity detected that this polymorphism increased cancer risk only in Asian populations. Then, trial sequential analyses demonstrated that the results of the meta-analysis were based on sufficient evidence. Therefore, this meta-analysis suggested that the PSCA rs2294008 C>T and rs2976392 G>A polymorphisms might be associated with cancer susceptibility, which might act as a potential predicted biomarker for genetic susceptibility to cancer, especially in gastric cancer and bladd er cancer.
以往的研究探讨了前列腺干细胞抗原（PSCA）基因rs2294008 C>T和rs2976392 G>A多态性与癌症易感性之间的关系。然而，现有研究结果仍不一致，甚至存在争议。因此，本荟萃分析旨在阐明这些关联。通过检索在线数据库PubMed、EMBASE和科学网，查找相关研究，涵盖截至2016年9月1日发表的所有论文。采用比值比（OR）及95%置信区间（CI）对数据进行合并，以评估这些关联的强度。然后，进行试验序贯分析，以估计结果的证据是否确凿。总体而言，PSCA rs2294008 C>T和rs2976392 G>A多态性与癌症风险显著增加相关。对于PSCA rs2294008多态性，按癌症类型分层时，结果在胃癌和膀胱癌中尤为显著。此外，在按种族进行的亚组分析中，亚洲和白种人群均检测到显著结果。同样，对于PSCA rs2976392多态性，按癌症类型进行的分层分析表明，结果仅在胃癌中显著。此外，按种族进行的分层分析发现，这种多态性仅在亚洲人群中增加癌症风险。然后，试验序贯分析表明，荟萃分析结果基于充分的证据。因此，本荟萃分析表明，PSCA rs2294008 C>T和rs2976392 G>A多态性可能与癌症易感性相关，这可能作为癌症遗传易感性的潜在预测生物标志物，尤其是在胃癌和膀胱癌中。
