West China School of Preclinical and Forensic Medicine, West China Second University Hospital, Sichuan University, Chengdu, PR China.
DNA Cell Biol. 2010 Jun;29(6):325-8. doi: 10.1089/dna.2009.0987.
CD86, one of the key costimulatory molecules, is not only involved in the initiation of T-cell immunity but also plays important roles in the development of cardiovascular diseases. The purpose of this study was to investigate the association between the CD86 polymorphism and the risk of coronary artery disease (CAD) in a Chinese population. We analyzed single-nucleotide polymorphism of CD86 +1057G/A (rs1129055) in 164 patients with CAD and 299 healthy controls by performing polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing assay. No significant association was observed in the genotype and allele frequencies of +1057G/A polymorphism between cases and controls, indicating that CD86 +1057G/A polymorphism may not be associated with CAD in the Chinese population.
CD86 是一种关键的共刺激分子，不仅参与 T 细胞免疫的启动，而且在心血管疾病的发展中发挥重要作用。本研究旨在探讨中国人群中 CD86 多态性与冠心病 (CAD) 风险之间的关系。我们通过聚合酶链反应-限制性片段长度多态性和 DNA 测序分析了 164 例 CAD 患者和 299 例健康对照者 CD86+1057G/A(rs1129055)单核苷酸多态性。病例组和对照组+1057G/A 多态性的基因型和等位基因频率无显著差异，表明 CD86+1057G/A 多态性与中国人群 CAD 无关。
