Department of Orthopedics, Shanghai Corps Hospital, Chinese People's Armed Police Forces, Changning, Shanghai, China.
DNA Cell Biol. 2012 Apr;31(4):537-40. doi: 10.1089/dna.2011.1370. Epub 2011 Aug 26.
The development of Ewing's sarcoma (ES) is a complex process resulting from interplay between mutations in oncogenes and tumor suppressors, host susceptibility factors, and cellular context. CD86 (B7-2) may affect cancer susceptibility by modulating T cell response. CD86 +1057G/A polymorphism (rs1129055) has been reported to be associated with various diseases. Here, we investigated the association between CD86 +1057G/A polymorphism and the risk of ES in a Chinese population. The CD86 +1057G/A polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in 158 ES cases and 212 age-matched healthy controls. Frequencies of CD86 +1057 AA genotype and +1057 A allele were significantly increased in patients with ES compared to healthy controls (odds ratio [OR]=2.12, 95% confidence interval [CI], 1.11-3.79, p=0.021; and OR=1.41, 95% CI, 1.10-1.91, p=0.018). Our data suggest that the +1057G/A polymorphism of the CD86 gene is associated with increased susceptibility to ES.
尤文肉瘤 (ES) 的发生是一个复杂的过程，源于癌基因和肿瘤抑制基因、宿主易感性因素和细胞环境之间的相互作用。CD86（B7-2）通过调节 T 细胞反应可能影响癌症易感性。已有报道称 CD86+1057G/A 多态性（rs1129055）与多种疾病相关。在此，我们在中国人群中研究了 CD86+1057G/A 多态性与 ES 风险的相关性。采用聚合酶链反应-限制性片段长度多态性检测 CD86+1057G/A 多态性，共纳入 158 例 ES 患者和 212 例年龄匹配的健康对照者。与健康对照组相比，ES 患者的 CD86+1057 AA 基因型和+1057 A 等位基因频率显著升高（比值比 [OR]=2.12，95%置信区间 [CI]，1.11-3.79，p=0.021；OR=1.41，95% CI，1.10-1.91，p=0.018）。我们的数据表明，CD86 基因的+1057G/A 多态性与 ES 的易感性增加相关。
