Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA.
Dev Cell. 2010 Mar 16;18(3):336-8. doi: 10.1016/j.devcel.2010.03.002.
Pre-mRNA splicing, once thought to be a strictly posttranscriptional event in gene expression, is subject to a multitiered network of regulation. Luco et al. now report in Science that this regulation seems to begin with chromatin modifications, suggesting that the histone code may be a prequel to the splicing code.
mRNA 前体剪接，曾一度被认为是基因表达中转录后严格发生的事件，现在受到多层次的调控网络的调控。Luco 等人现在在《科学》杂志上报告称，这种调控似乎始于染色质修饰，这表明组蛋白密码可能是剪接密码的前奏。
