染色质：剪接调控的终极疆域？
Chromatin: the final frontier in splicing regulation?
机构信息
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA.
出版信息
Dev Cell. 2010 Mar 16;18(3):336-8. doi: 10.1016/j.devcel.2010.03.002.
Abstract
Pre-mRNA splicing, once thought to be a strictly posttranscriptional event in gene expression, is subject to a multitiered network of regulation. Luco et al. now report in Science that this regulation seems to begin with chromatin modifications, suggesting that the histone code may be a prequel to the splicing code.
摘要
mRNA 前体剪接，曾一度被认为是基因表达中转录后严格发生的事件，现在受到多层次的调控网络的调控。Luco 等人现在在《科学》杂志上报告称，这种调控似乎始于染色质修饰，这表明组蛋白密码可能是剪接密码的前奏。
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本文引用的文献
1
Regulation of alternative splicing by histone modifications.组蛋白修饰调控可变剪接。
Science. 2010 Feb 19;327(5968):996-1000. doi: 10.1126/science.1184208. Epub 2010 Feb 4.
2
Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping.全基因组分析表明 PTB-RNA 相互作用揭示了一般剪接抑制剂用来调节外显子包含或跳过的策略。
Mol Cell. 2009 Dec 25;36(6):996-1006. doi: 10.1016/j.molcel.2009.12.003.
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Biased chromatin signatures around polyadenylation sites and exons.多聚腺苷酸化位点和外显子周围的染色质特征偏差。
Mol Cell. 2009 Oct 23;36(2):245-54. doi: 10.1016/j.molcel.2009.10.008.
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Nucleosomes are well positioned in exons and carry characteristic histone modifications.核小体在外显子中定位良好，并带有特征性的组蛋白修饰。
Genome Res. 2009 Oct;19(10):1732-41. doi: 10.1101/gr.092353.109. Epub 2009 Aug 17.
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Chromatin organization marks exon-intron structure.染色质组织标记外显子-内含子结构。
Nat Struct Mol Biol. 2009 Sep;16(9):990-5. doi: 10.1038/nsmb.1659.
6
Nucleosome positioning as a determinant of exon recognition.核小体定位作为外显子识别的一个决定因素。
Nat Struct Mol Biol. 2009 Sep;16(9):996-1001. doi: 10.1038/nsmb.1658.
7
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