College of Science, Northwest A&F University, Yangling 712100, PR China.
Fitoterapia. 2010 Sep;81(6):636-9. doi: 10.1016/j.fitote.2010.03.009. Epub 2010 Mar 15.
Two new bufadienolides, named tigencaoside A(1) and tigencaoside B(2), were isolated from the rhizomes of Helleborus thibetanus Franch., along with two known bufadienolides, hellebrigenin (3) and 5beta,14beta-dihydroxy-19-oxo-3beta-[(alpha-L-rhamnopyranosyl)oxy]bufa-20,22-dienolide (4). Their structures were elucidated on the basis of extensive spectroscopic analysis. Two new compounds were evaluated for their cytotoxic activities against four strains of cultured tumor cells.
从藏白头翁的根茎中分离得到了两个新的蟾毒配基，分别命名为嚏根草苷 A（1）和嚏根草苷 B（2），以及两个已知的蟾毒配基，嚏根草苷（3）和 5β，14β-二羟基-19-氧-3β-[(α-L-鼠李吡喃糖基)氧基]蟾毒-20，22-二烯醇（4）。基于广泛的光谱分析，确定了它们的结构。对两种新化合物进行了针对四种培养肿瘤细胞株的细胞毒性活性评价。
