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从西藏铁筷子根茎中分离出的两种具有抗前列腺癌细胞活性的新蟾蜍二烯内酯。

Two new bufadienolides from the rhizomes of Helleborus thibetanus with inhibitory activities against prostate cancer cells.

作者信息

Cheng Wei, Tan Ya-Fang, Tian Hai-Yan, Gong Xiang-Wen, Chen Ke-Li, Jiang Ren-Wang

机构信息

a Key Laboratory of Traditional Chinese Medicine Resource and Compound Prescription, Ministry of Education , Hubei University of Traditional Chinese Medicine , Wuhan 430065 , P.R. China.

出版信息

Nat Prod Res. 2014;28(12):901-8. doi: 10.1080/14786419.2014.891200. Epub 2014 Apr 4.

DOI:10.1080/14786419.2014.891200
PMID:24697315
Abstract

Two new bufadienolide glycosides (1 and 2) with an A/B trans ring fusion together with nine known compounds (3-11) were isolated from the rhizomes of Helleborus thibetanus. The structures of new compounds were elucidated by extensive spectroscopic analyses in combination with single-crystal X-ray diffraction. The bufadienolides 1 and 3-6 exhibited potent cytotoxic activities against the prostate cancer cells.

摘要

从西藏铁筷子的根茎中分离出两种具有A/B反式环稠合的新蟾蜍二烯内酯苷（1和2）以及九种已知化合物（3-11）。通过广泛的光谱分析结合单晶X射线衍射阐明了新化合物的结构。蟾蜍二烯内酯1和3-6对前列腺癌细胞表现出强大的细胞毒性活性。

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