从椭圆藤黄中提取的细胞毒性多异戊二烯基二苯甲酮类化合物。
Cytotoxic polyisoprenyl benzophenonoids from Garcinia subelliptica.
机构信息
National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China.
出版信息
J Nat Prod. 2010 Apr 23;73(4):557-62. doi: 10.1021/np900620y.
Abstract
Six new polyisoprenyl benzophenonoids, (+/-)-garcinialiptone A (1, 2), garcinialiptone B (3), (-)-cycloxanthochymol (4), garcinialiptone C (5), and garcinialiptone D (6), along with three known compounds, xanthochymol (7), isoxanthochymol (8), and cycloxanthochymol (9), were isolated from the fruits of Garcinia subelliptica. The structures of 1-6 were elucidated by spectroscopic analysis. Biological evaluation showed that all compounds 1-9 exhibited cytotoxic activity against a small panel of human tumor cell lines (A549, DU145, KB, vincristine-resistant KB).
摘要
从余甘子 Garcinia subelliptica 的果实中分离得到 6 个新的多异戊烯基二苯甲酮类化合物（±）-garcinialiptone A（1、2）、garcinialiptone B（3）、（-）-cycloxanthochymol（4）、garcinialiptone C（5）和 garcinialiptone D（6），以及 3 个已知化合物黄烷醇（7）、异黄烷醇（8）和环黄烷醇（9）。通过光谱分析阐明了 1-6 的结构。生物活性评价表明，所有化合物 1-9 对一组人肿瘤细胞系（A549、DU145、KB、长春新碱耐药 KB）均具有细胞毒性活性。
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