氢氧化四甲铵（TMAH）飞溅物的去污处理：Diphoterine体外实验取得有前景的结果。

Decontamination of tetramethylammonium hydroxide (TMAH) splashes: promising results with Diphoterine in vitro.

作者信息

Fosse Céline, Mathieu Laurence, Hall Alan H, Bocchietto Elena, Burgher François, Fischbach Michel, Maibach Howard I

机构信息

Laboratoire Prevor, Valmondois, France.

出版信息

Cutan Ocul Toxicol. 2010 Jun;29(2):110-5. doi: 10.3109/15569521003661288.

DOI:10.3109/15569521003661288

PMID:20233016

Abstract

Tetramethylammonium hydroxide (TMAH), used in microelectronic industries and research and development, has both corrosive properties and systemic toxicity. Two fatal TMAH occupational exposure cases have been published. Studies comparing initial TMAH decontamination with Diphoterine versus tap water were performed: an in vitro pH titration study and an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) in vitro cytotoxicity cell viability assay. For pH normalization, 17 times more tap water than Diphoterine was required. In the cytotoxicity test, two-thirds of the cells remained viable after Diphoterine washing, compared with only one-third after tap water washing (p < .001). Diphoterine washing is a promising TMAH decontamination method.

摘要

用于微电子行业及研发的氢氧化四甲铵（TMAH）具有腐蚀性和全身毒性。已发表了两起TMAH职业暴露致死案例。开展了将Diphoterine与自来水用于TMAH初始去污的对比研究：一项体外pH滴定研究以及一项MTT（3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐）体外细胞毒性细胞活力测定。为使pH正常化，所需自来水的量是Diphoterine的17倍。在细胞毒性试验中，经Diphoterine清洗后，三分之二的细胞仍存活，而经自来水清洗后只有三分之一的细胞存活（p < 0.001）。Diphoterine清洗是一种很有前景的TMAH去污方法。