用于氧化铝精炼厂皮肤碱化学溅出的二膦酸酯。

Diphoterine for alkali chemical splashes to the skin at alumina refineries.

机构信息

Alcoa of Australia, Perth, WA, Australia.

出版信息

Int J Dermatol. 2010 Aug;49(8):894-900. doi: 10.1111/j.1365-4632.2009.04397.x.

DOI:10.1111/j.1365-4632.2009.04397.x

PMID:21174372

Abstract

BACKGROUND

Diphoterine is a commercially available amphoteric, hypertonic, chelating solution used to decontaminate and irrigate chemical splashes. The aim of this study was to evaluate the implementation of Diphoterine at three alumina refineries. This is the largest case series reported to date.

METHODS

One hundred eighty cases of alkali splashes to the skin were evaluated clinically. Two groups were compared; those who had applied Diphoterine first and those who had applied water first.

RESULTS

There were no signs of chemical burn in 52.9% of the group who applied Diphoterine first compared with 21.4% of the group who applied water first. Only 7.9% of the group who applied Diphoterine first had blisters or more severe signs compared with 23.8% of the group who applied water first. The differences were statistically significant (P < 0.001). After implementation of Diphoterine the "first aid" injury rate for chemical burns fell 24.7% (95% CI 0.5–43.0%).

CONCLUSIONS

Applying Diphoterine first was associated with significantly better outcomes following alkali skin splashes than applying water first.

摘要

背景

二聚体是一种市售的两性、高渗、螯合溶液，用于清除和冲洗化学溅出物。本研究旨在评估 Diphoterine 在三家氧化铝精炼厂的实施情况。这是迄今为止报告的最大病例系列。

方法

临床评估了 180 例皮肤碱溅伤病例。比较了两组：先用 Diphoterine 处理的组和先用水处理的组。

结果

先用 Diphoterine 处理的组中，有 52.9%没有出现化学灼伤迹象，而先用水处理的组中只有 21.4%。先用 Diphoterine 处理的组中只有 7.9%出现水疱或更严重的迹象，而先用水处理的组中则有 23.8%。差异具有统计学意义（P<0.001）。实施 Diphoterine 后，化学烧伤的“急救”伤害率下降了 24.7%（95%CI 0.5-43.0%）。