Department of Gynaecological Oncology, University of Turin, Mauriziano Umberto I Hospital and Institute for Cancer Research and Treatment of Candiolo (IRCC), Turin, Italy.
J Sex Med. 2010 May;7(5):1891-900. doi: 10.1111/j.1743-6109.2010.01725.x. Epub 2010 Mar 2.
Breast cancer and its treatment negatively affect the important aspects of a woman's life such as sexual health, cognitive functions, body image, and weight. Abrupt estrogen deficiency following chemotherapy and/or hormonal therapy plays an important role in worsening of sexuality.
To evaluate the impact of breast cancer treatment on sexual functioning, cognitive function, and body weight in premenopausal women.
Thirty-five women with a premenopausal diagnosis of breast cancer who are candidate to adjuvant treatment completed validated questionnaires on menopausal symptoms, sexuality, partner relationship, depression, body image, and cognitive functions after surgery (T0), then after chemotherapy or at least 6 months of endocrine therapy (T1), and after 1 year (T2). In addition, gynecological and dietological examinations were performed.
The following validated questionnaires were used: Greene Climacteric Scale, Beck Depression Inventory, Body Attitude Test, McCoy revised Italian version McCoy Female Sexuality Questionnaire, Cues for Sexual Desire Scale, Dyadic Adjustment Scale, Numeric Matrix Test and Rey auditory-verbal learning test, to measure cognitive functions, a recall 24 H questionnaire to evaluate food intake, Minnesota Leisure Time Physical Activity questionnaire and Eating Attitude Test-40, while anthropometric and plicometry data were assessed by a dietitian.
Low levels of sexual functioning were registered at baseline; a further decrease in sexual activity, quality of the partnered relationship, desire, and arousability was demonstrated at T1 and T2. We found a significant increase in hot flushes and anxiety. Nonsignificant deterioration of body image was demonstrated. Although women reported losing memory and concentration, "chemobrain" effect was not demonstrated as cognitive tests improved after 6 months, probably because of "learning effect." Women who had undergone chemotherapy gained weight and fat disposition was typically android.
Young women undergoing adjuvant breast cancer therapy experience a heavy impairment in important quality of life domains as sexuality and targeted support interventions are needed.
乳腺癌及其治疗会对女性生活的重要方面产生负面影响，如性健康、认知功能、身体形象和体重。化疗和/或激素治疗后雌激素的突然缺乏在性功能恶化中起着重要作用。
评估乳腺癌治疗对绝经前妇女性功能、认知功能和体重的影响。
35 名被诊断为乳腺癌且处于绝经前的女性在手术后（T0）、化疗后或至少 6 个月内分泌治疗后（T1）以及 1 年后（T2）完成了关于更年期症状、性健康、伴侣关系、抑郁、身体形象和认知功能的经过验证的问卷。此外，还进行了妇科和饮食学检查。
使用以下经过验证的问卷：格林绝经量表、贝克抑郁量表、身体态度测试、麦考伊修订的意大利版麦考伊女性性健康问卷、性唤起线索量表、对偶调整量表、数字矩阵测试和雷听觉语言学习测试，以评估认知功能；使用 24 小时回忆问卷评估食物摄入量；明尼苏达州休闲时间体力活动问卷和饮食态度测试-40。营养师评估了人体测量和皮褶厚度数据。
基线时性健康水平较低；在 T1 和 T2 时，性活动、伴侣关系质量、欲望和唤起能力进一步下降。我们发现热潮和焦虑显著增加。身体形象没有明显恶化。尽管女性报告记忆力和注意力下降，但认知测试在 6 个月后有所改善，表明“化疗脑”效应并未出现，这可能是因为“学习效应”。接受化疗的女性体重增加，脂肪分布通常呈男性型。
接受辅助乳腺癌治疗的年轻女性在性健康和认知功能等重要生活质量领域经历了严重的损害，需要针对性的支持干预措施。
