Touyz S W, Beumont P J, Saayman G S, Zabow T
Biol Psychiatry. 1977 Dec;12(6):801-22.
A nine consecutive night, double-blind design was used to assess the effects of a psychotropic agent (clozapine) upon sleep parameters as well as measures of mood and performance in a group of seven normal, young adults. Placebo was administered to a control group of seven subjects. EEGs and EOGs were monitored throughout the night in a laboratory environment and were scored according to standardized criteria. The administration of 25 mg clozapine/night for three consecutive nights significantly reduced stage 4 sleep on the second and third nights. Whereas stage REM sleep was not affected, a variety of REM indices were significantly increased on the third night of clozapine administration and/or on the first night of clozapine withdrawal. The number of body movements and the number of body movements/minute of sleep were significantly reduced on the three nights of clozapine administration. Numerous psychophysiological side effects were reported. These results indicate that clozapine may be a useful medication in the treatment of sleep disorders. However, the incidence of adverse side effects of represents a major limitation in the use of clozapine as an hypnotic agent at the dose-rate employed.
采用连续九晚的双盲设计，评估一种精神药物（氯氮平）对一组七名正常年轻成年人睡眠参数以及情绪和行为指标的影响。给七名受试者组成的对照组服用安慰剂。在实验室环境中对脑电图（EEG）和眼电图（EOG）进行整夜监测，并根据标准化标准进行评分。连续三晚每晚服用25毫克氯氮平，在第二晚和第三晚显著减少了慢波睡眠4期。虽然快速眼动（REM）睡眠期未受影响，但在服用氯氮平的第三晚和/或停用氯氮平的第一晚，多种REM指标显著增加。在服用氯氮平的三个晚上，身体运动次数和每分钟睡眠中的身体运动次数显著减少。报告了许多心理生理副作用。这些结果表明氯氮平可能是治疗睡眠障碍的一种有用药物。然而，在所采用的剂量率下，不良反应的发生率是将氯氮平用作催眠剂的一个主要限制。
