Kuz'minskaia U A, Bersan L V, Pis'mennaia M V
Biull Eksp Biol Med. 1977 Dec;84(12):677-9.
The activity of hexokinase, glucose-6-phosphatase and glucose-6-phosphoric dehydrogenase was studied in the liver of rats after one hour, one and five days after a single oral administration of organic phosphorus insecticide valekson. It was determined that administration of the preparation led to an increase of activity in the homogenate and solubilization of glucose-6-phosphatase, activation of glucose-6-phosphoric dehydrogenase and inhibition of hexokinase. The changes were maximum one hour after the administration of the compound. The results show that a decrease of the intensity of glucose-6-phosphate formation and metabolism is one of the pathogenetic factors in the development of valekson-induced intoxication.
单次口服有机磷杀虫剂伐灭磷后1小时、1天和5天，研究了大鼠肝脏中己糖激酶、葡萄糖-6-磷酸酶和葡萄糖-6-磷酸脱氢酶的活性。结果表明，给予该制剂导致匀浆中葡萄糖-6-磷酸酶活性增加和溶解，葡萄糖-6-磷酸脱氢酶被激活，己糖激酶受到抑制。给药后1小时这些变化最为明显。结果表明，葡萄糖-6-磷酸生成和代谢强度降低是伐灭磷诱导中毒发生发展的致病因素之一。
