Smoliar V i, Tsapko E V, Karpilovskaia E D, Pliss M B, Saliĭ N S, Grigorenko S N
Vopr Pitan. 1993 Jan-Feb(1):38-40.
A trial has been performed of a new sweetening agent saccharol, glycosides complex, on energy metabolism in rats with experimental alloxan diabetes. Elevated glucose level observed in rats with insulin insufficiency was associated with hexokinase activity inhibition and changes in the activity of the enzymes involved in glucose-6-phosphate transformation: enhanced activity of glucose-6-phosphatase and glucose-6-phosphate dehydrogenase against inhibition of phosphoglucomutase activity. Introduction of saccharose aggravated the above shifts in the rat liver, whereas saccharol possesses a protective action on hexokinase hepatic reaction and enzymes of glucose-6-phosphate conversion, reduced blood glucose. Positive changes induced by saccharol on energy metabolism in animals with insulin insufficiency can be attributed to the effect of saccharol glycosides.
已对一种新型甜味剂糖醇（糖苷复合物）进行了试验，研究其对实验性四氧嘧啶糖尿病大鼠能量代谢的影响。在胰岛素不足的大鼠中观察到的血糖水平升高与己糖激酶活性抑制以及参与葡萄糖 - 6 - 磷酸转化的酶活性变化有关：葡萄糖 - 6 - 磷酸酶和葡萄糖 - 6 - 磷酸脱氢酶的活性增强，而磷酸葡萄糖变位酶活性受到抑制。蔗糖的引入加剧了大鼠肝脏中的上述变化，而糖醇对肝脏己糖激酶反应和葡萄糖 - 6 - 磷酸转化酶具有保护作用，可降低血糖。糖醇对胰岛素不足动物能量代谢的积极影响可归因于糖醇糖苷的作用。
