Schreiber W, Schweiger U, Werner D, Brunner G, Tuschl R J, Laessle R G, Krieg J C, Fichter M M, Pirke K M
Max Planck Institute of Psychiatry, Munich, Germany.
Metabolism. 1991 May;40(5):503-7. doi: 10.1016/0026-0495(91)90231-k.
Insulin, glucose, and large neutral amino acids (LNAA) were studied in 10 patients with anorexia nervosa, 13 patients with bulimia nervosa, and 15 healthy controls. Blood samples were collected at hourly intervals during the day and at two-hour intervals during the night over a 24-hour period. Ad libitum caloric and relative carbohydrate intake was significantly reduced in the anorectic and bulimic patients. Elevated concentrations of beta-hydroxybutyric acid (BHBA) were seen in the bulimic group, and low triiodothyronine (T3) concentrations in the anorectic group. Mean plasma glucose and insulin concentrations were significantly lowered in both groups. The tryptophan (Trp) to LNAA ratio was reduced in anorectic, but not in bulimic patients. These findings suggest that Trp influx into the brain is reduced in anorectic patients, possibly impairing central serotonergic function.
对10名神经性厌食症患者、13名神经性贪食症患者和15名健康对照者的胰岛素、葡萄糖和大中性氨基酸（LNAA）进行了研究。在24小时内，白天每隔一小时、夜间每隔两小时采集血样。神经性厌食症和神经性贪食症患者的随意热量摄入和相对碳水化合物摄入量显著降低。神经性贪食症组的β-羟基丁酸（BHBA）浓度升高，神经性厌食症组的三碘甲状腺原氨酸（T3）浓度降低。两组的平均血浆葡萄糖和胰岛素浓度均显著降低。神经性厌食症患者的色氨酸（Trp）与LNAA比值降低，但神经性贪食症患者未降低。这些发现表明，神经性厌食症患者大脑中的色氨酸流入减少，可能会损害中枢5-羟色胺能功能。
