Department of Infectious Diseases, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.
Microbiol Immunol. 2010 Mar;54(3):170-4. doi: 10.1111/j.1348-0421.2010.00199.x.
M.tb is an intracellular pathogen which survives within the phagosomes of host macrophages by inhibiting their fusion with lysosomes. Here, it has been demonstrated that a lysosomal glycoprotein, CD63, is recruited to the majority of M.tb phagosomes, while RILP shows limited localization. This is consistent with the author's findings that CD63, but not RILP, is recruited to the phagosomes in macrophages expressing the dominant negative form of Rab7. These results suggest that M.tb phagosomes selectively fuse with endosomes and lysosomes to escape killing activity while acquiring nutrients.
M.tb 是一种细胞内病原体，它通过抑制与溶酶体融合来在宿主巨噬细胞的吞噬体中存活。在这里，已经证明溶酶体糖蛋白 CD63 被招募到大多数 M.tb 吞噬体中，而 RILP 的定位则很有限。这与作者的发现一致，即在表达 Rab7 显性负形式的巨噬细胞中，只有 CD63 而不是 RILP 被招募到吞噬体中。这些结果表明，M.tb 吞噬体选择性地与内体和溶酶体融合，以逃避杀伤活性并获取营养。
