University of Giessen Lung Center, Medical Clinic II, Justus-Liebig-University Giessen, Klinikstrasse 36, Giessen, Germany.
Crit Care. 2010;14(2):128. doi: 10.1186/cc8882. Epub 2010 Mar 10.
Lipid emulsions based on soybean oil have been an integral part of parenteral nutrition supplying n-6 fatty acids, with possible negative effects in critically ill patients. Newer lipid emulsions supply less n-6 fatty acids. In addition, fish oil-based lipids may be included in the lipid component of parenteral nutrition. While clinical benefits of lipid emulsions with a reduced fraction in n-6 lipids and the addition of fish oil have been described in postoperative patients, data are less clear in critically ill or septic patients. Recent data suggest that beneficial effects may be achieved when used early but clearly more data are needed to come to a definitive conclusion. The present commentary will highlight current data in critically ill and septic patients and the use of fish oil as a part of parenteral nutrition.
基于大豆油的脂肪乳剂一直是肠外营养的重要组成部分，可提供 n-6 脂肪酸，但可能对危重症患者有负面影响。新型脂肪乳剂提供的 n-6 脂肪酸较少。此外，肠外营养的脂肪成分中还可包含鱼油。虽然已在术后患者中描述了减少 n-6 脂质部分和添加鱼油的脂肪乳剂的临床益处，但在危重症或脓毒症患者中的数据则不太明确。最近的数据表明，早期使用可能会产生有益效果，但显然还需要更多的数据来得出明确的结论。本述评将重点介绍目前在危重症和脓毒症患者中使用鱼油作为肠外营养一部分的相关数据。
