Pharmacy Department, National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Am J Health Syst Pharm. 2010 Apr 1;67(7):562-5. doi: 10.2146/ajhp090342.
The physical compatibility of magnesium sulfate and sodium bicarbonate in a pharmacy-compounded hemofiltration solution was assessed.
Two bicarbonate-buffered hemofiltration solutions (low- and high-magnesium formulations) were compounded in triplicate. The concentrations of magnesium (15 meq/L) and sodium bicarbonate (50 meq/L) in the high-magnesium formulation were chosen to be somewhat below the concentrations reported as being incompatible in a popular reference. The six hemofiltration bags were stored at 22-25 degrees C without protection from light for 48 hours. Physical compatibility was assessed by visual inspection and microscopy. The pH of the solutions was assayed 3-4 and 52-53 hours after compounding. Electrolyte and glucose concentrations of the solutions were assayed at 3-4 and 50-51 hours after preparation.
No particulate matter was observed by visual or microscopic inspection in the compounded hemofiltration solutions at 48 hours. The mean +/- S.D. pH values of the low-magnesium solutions were 8.01 +/- 0.02 and 8.04 +/- 0.02 at 3-4 and 52-53 hours after compounding, respectively. The mean +/- S.D. pH values of the high-magnesium solutions were 7.96 +/- 0.02 and 7.98 +/- 0.01 at 3-4 and 52-53 hours after compounding, respectively. The electrolyte and glucose concentrations in the low- and high-magnesium solutions were similar 3-4 and 50-51 hours after preparation.
Magnesium sulfate 1.5 meq/L and sodium bicarbonate 50 meq/L were physically compatible in a pharmacy-compounded hemofiltration solution for 48 hours when stored at 22-25 degrees C without protection from light.
评估在药房配制的血液滤过溶液中硫酸镁和碳酸氢钠的物理相容性。
重复配制了两种碳酸氢盐缓冲血液滤过溶液（低镁和高镁配方）。高镁配方中选择的镁（15 meq/L）和碳酸氢钠（50 meq/L）浓度略低于在一个流行参考中报告的不相容浓度。在没有避光保护的情况下，将六个血液滤过袋储存在 22-25°C 下 48 小时。通过目视检查和显微镜检查评估物理相容性。在配制后 3-4 小时和 52-53 小时测定溶液的 pH 值。在配制后 3-4 小时和 50-51 小时测定溶液的电解质和葡萄糖浓度。
在 48 小时时，通过目视或显微镜检查，在配制的血液滤过溶液中未观察到颗粒物质。低镁溶液的平均 +/- S.D. pH 值分别为 8.01 +/- 0.02 和 8.04 +/- 0.02，在配制后 3-4 小时和 52-53 小时。高镁溶液的平均 +/- S.D. pH 值分别为 7.96 +/- 0.02 和 7.98 +/- 0.01，在配制后 3-4 小时和 52-53 小时。低镁和高镁溶液中的电解质和葡萄糖浓度在配制后 3-4 小时和 50-51 小时相似。
在 22-25°C 下储存且没有避光保护的情况下，药房配制的血液滤过溶液中硫酸镁 1.5 meq/L 和碳酸氢钠 50 meq/L 在 48 小时内物理相容。
