人源胃固有树突状细胞可诱导针对 H. pylori 的 Th1 应答。
Human primary gastric dendritic cells induce a Th1 response to H. pylori.
机构信息
Department of Medicine (Gastroenterology), University of Alabama at Birmingham, Birmingham, Alabama, USA.
出版信息
Mucosal Immunol. 2010 May;3(3):260-9. doi: 10.1038/mi.2010.10. Epub 2010 Mar 17.
Abstract
Adaptive CD4 T-cell responses are important in the pathogenesis of chronic Helicobacter pylori gastritis. However, the gastric antigen-presenting cells that induce these responses have not yet been identified. Here we show that dendritic cells (DCs) are present in the gastric mucosa of healthy subjects and are more prevalent and more activated in the gastric mucosa of H. pylori-infected subjects. H. pylori induced gastric DCs isolated from noninfected subjects to express increased levels of CD11c, CD86 and CD83, and to secrete proinflammatory cytokines, particularly interleukin (IL)-6 and IL-8. Importantly, gastric DCs pulsed with live H. pylori, but not control DCs, mediated T-cell secretion of interferon-gamma. The ability of H. pylori to induce gastric DC maturation and stimulate gastric DC activation of Th1 cells implicates gastric DCs as initiators of the immune response to H. pylori.
摘要
适应性 CD4 T 细胞反应在慢性幽门螺杆菌胃炎的发病机制中很重要。然而，诱导这些反应的胃抗原呈递细胞尚未被鉴定。在这里，我们表明树突状细胞（DC）存在于健康受试者的胃黏膜中，并且在幽门螺杆菌感染受试者的胃黏膜中更为普遍和更活跃。幽门螺杆菌诱导从未感染受试者中分离出的胃 DC 表达更高水平的 CD11c、CD86 和 CD83，并分泌促炎细胞因子，特别是白细胞介素（IL）-6 和 IL-8。重要的是，用活幽门螺杆菌冲击的胃 DC 而非对照 DC 介导 T 细胞分泌干扰素-γ。幽门螺杆菌诱导胃 DC 成熟并刺激胃 DC 激活 Th1 细胞的能力表明胃 DC 是对幽门螺杆菌免疫反应的启动者。
相似文献
1
Human primary gastric dendritic cells induce a Th1 response to H. pylori.人源胃固有树突状细胞可诱导针对 H. pylori 的 Th1 应答。
Mucosal Immunol. 2010 May;3(3):260-9. doi: 10.1038/mi.2010.10. Epub 2010 Mar 17.
2
Helicobacter pylori stimulates dendritic cells to induce interleukin-17 expression from CD4+ T lymphocytes.幽门螺杆菌刺激树突状细胞诱导 CD4+T 淋巴细胞表达白细胞介素-17。
Infect Immun. 2010 Feb;78(2):845-53. doi: 10.1128/IAI.00524-09. Epub 2009 Nov 16.
3
Involvement of myeloid dendritic cells in the development of gastric secondary lymphoid follicles in Helicobacter pylori-infected neonatally thymectomized BALB/c mice.髓样树突状细胞在新生期胸腺切除的幽门螺杆菌感染BALB/c小鼠胃次级淋巴滤泡发育中的作用
Infect Immun. 2003 Apr;71(4):2153-62. doi: 10.1128/IAI.71.4.2153-2162.2003.
4
Chronic exposure to Helicobacter pylori impairs dendritic cell function and inhibits Th1 development.长期暴露于幽门螺旋杆菌会损害树突状细胞功能并抑制Th1细胞发育。
Infect Immun. 2007 Feb;75(2):810-9. doi: 10.1128/IAI.00228-06. Epub 2006 Nov 13.
5
Stimulation of dendritic cells with Helicobacter pylori vacuolating cytotoxin negatively regulates their maturation via the restoration of E2F1.幽门螺杆菌空泡细胞毒素刺激树突状细胞通过恢复 E2F1 负调控其成熟。
Clin Exp Immunol. 2011 Oct;166(1):34-45. doi: 10.1111/j.1365-2249.2011.04447.x.
6
Human dendritic cells respond to Helicobacter pylori, promoting NK cell and Th1-effector responses in vitro.人类树突状细胞对幽门螺杆菌产生反应，在体外促进自然杀伤细胞和Th1效应反应。
J Immunol. 2004 Jul 15;173(2):1249-57. doi: 10.4049/jimmunol.173.2.1249.
7
Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunity to Helicobacter pylori.Toll样受体依赖性抗原呈递细胞的激活影响对幽门螺杆菌的适应性免疫。
Gastroenterology. 2007 Jul;133(1):150-163.e3. doi: 10.1053/j.gastro.2007.04.071. Epub 2007 May 3.
8
Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice.幽门螺杆菌免疫逃逸是由树突状细胞诱导的 Treg 偏倚和 Th17 抑制介导的。
Gastroenterology. 2010 Mar;138(3):1046-54. doi: 10.1053/j.gastro.2009.11.043. Epub 2009 Nov 18.
9
Dendritic cell function in the host response to Helicobacter pylori infection of the gastric mucosa.树突状细胞在宿主对胃黏膜幽门螺杆菌感染的反应中的作用。
Pathog Dis. 2013 Feb;67(1):46-53. doi: 10.1111/2049-632X.12014. Epub 2013 Jan 22.
10
[Relation between gastric dendritic cells and H pylori-associated gastritis].[胃树突状细胞与幽门螺杆菌相关性胃炎的关系]
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Aug;27(8):899-900.
引用本文的文献
1
Innate Immunity in Helicobacter pylori Infection and Gastric Oncogenesis.幽门螺杆菌感染与胃癌发生中的天然免疫
Helicobacter. 2025 Mar-Apr;30(2):e70015. doi: 10.1111/hel.70015.
2
Gastrointestinal cancer resistance to treatment: the role of microbiota.胃肠道癌症的治疗耐药性：微生物群的作用
Infect Agent Cancer. 2024 Oct 5;19(1):50. doi: 10.1186/s13027-024-00605-3.
3
ADP-heptose attenuates -induced dendritic cell activation.ADP-庚糖可减弱 LPS 诱导的树突状细胞活化。
Gut Microbes. 2024 Jan-Dec;16(1):2402543. doi: 10.1080/19490976.2024.2402543. Epub 2024 Sep 17.
4
An M cell-targeting recombinant L. lactis vaccine against four H. pylori adhesins.一种针对四种 H. pylori 黏附素的 M 细胞靶向重组乳杆菌疫苗。
Appl Microbiol Biotechnol. 2024 Feb 23;108(1):231. doi: 10.1007/s00253-024-13070-0.
5
Effects of infection on intestinal microbiota, immunity and colorectal cancer risk.感染对肠道微生物群、免疫和结直肠癌风险的影响。
Front Cell Infect Microbiol. 2024 Jan 26;14:1339750. doi: 10.3389/fcimb.2024.1339750. eCollection 2024.
6
Immune Biology and Persistence of Helicobacter pylori in Gastric Diseases.幽门螺杆菌在胃部疾病中的免疫生物学和持久性。
Curr Top Microbiol Immunol. 2023;444:83-115. doi: 10.1007/978-3-031-47331-9_4.
7
actively suppresses innate immune nucleic acid receptors.积极抑制先天免疫核酸受体。
Gut Microbes. 2022 Jan-Dec;14(1):2105102. doi: 10.1080/19490976.2022.2105102.
8
Innate Immunity Crosstalk with : Pattern Recognition Receptors and Cellular Responses.先天免疫与：模式识别受体和细胞反应的相互作用。
Int J Mol Sci. 2022 Jul 8;23(14):7561. doi: 10.3390/ijms23147561.
9
Infection of Primary Human Monocytes Boosts Subsequent Immune Responses to LPS.原发性人单核细胞感染可增强对 LPS 的后续免疫反应。
Front Immunol. 2022 Mar 2;13:847958. doi: 10.3389/fimmu.2022.847958. eCollection 2022.
10
Gelsolin Can Be a Prognostic Biomarker and Correlated with Immune Infiltrates in Gastric Cancer.凝溶胶蛋白可作为胃癌的预后生物标志物并与免疫浸润相关。
Int J Gen Med. 2022 Jan 27;15:927-936. doi: 10.2147/IJGM.S339940. eCollection 2022.
本文引用的文献
1
Essential role for macrophage migration inhibitory factor in gastritis induced by Helicobacter pylori.巨噬细胞移动抑制因子在幽门螺杆菌诱导的胃炎中的重要作用。
Am J Pathol. 2009 Apr;174(4):1319-28. doi: 10.2353/ajpath.2009.080708. Epub 2009 Mar 12.
2
Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori.细胞外和细胞内模式识别受体在幽门螺杆菌的识别中协同作用。
Gastroenterology. 2009 Jun;136(7):2247-57. doi: 10.1053/j.gastro.2009.02.066. Epub 2009 Mar 6.
3
Helicobacter pylori-induced interleukin-12 p40 expression.幽门螺杆菌诱导的白细胞介素-12 p40表达。
Infect Immun. 2009 Apr;77(4):1337-48. doi: 10.1128/IAI.01456-08. Epub 2009 Jan 29.
4
Tuning microenvironments: induction of regulatory T cells by dendritic cells.调节微环境：树突状细胞对调节性T细胞的诱导
Immunity. 2008 Sep 19;29(3):362-71. doi: 10.1016/j.immuni.2008.08.005.
5
Helicobacter pylori invades the gastric mucosa and translocates to the gastric lymph nodes.幽门螺杆菌侵入胃黏膜并转移至胃淋巴结。
Lab Invest. 2008 Jun;88(6):664-81. doi: 10.1038/labinvest.2008.33. Epub 2008 May 12.
6
Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses.幽门螺杆菌引起的消化性溃疡疾病与调节性T细胞反应不足有关。
Gut. 2008 Oct;57(10):1375-85. doi: 10.1136/gut.2007.137539. Epub 2008 May 8.
7
Helicobacter pylori-pulsed dendritic cells induce H. pylori-specific immunity in mice.幽门螺杆菌脉冲树突状细胞在小鼠中诱导幽门螺杆菌特异性免疫。
Helicobacter. 2008 Jun;13(3):200-8. doi: 10.1111/j.1523-5378.2008.00606.x.
8
Isolation and purification of human intestinal macrophages.人肠道巨噬细胞的分离与纯化。
Curr Protoc Immunol. 2006 Jan;Chapter 7:7.6B.1-7.6B.9. doi: 10.1002/0471142735.im0706bs70.
9
Colocalization of fluorescent markers in confocal microscope images of plant cells.植物细胞共聚焦显微镜图像中荧光标记的共定位。
Nat Protoc. 2008;3(4):619-28. doi: 10.1038/nprot.2008.31.
10
Helicobacter pylori gastritis in children is associated with a regulatory T-cell response.儿童幽门螺杆菌胃炎与调节性T细胞反应有关。
Gastroenterology. 2008 Feb;134(2):491-9. doi: 10.1053/j.gastro.2007.11.006. Epub 2007 Nov 4.
Zotero 插件