Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
Int J Mol Sci. 2022 Jul 8;23(14):7561. doi: 10.3390/ijms23147561.
is one of the most successful gastric pathogens that has co-existed with human for centuries. is recognized by the host immune system through human pattern recognition receptors (PRRs), such as toll-like receptors (TLRs), C-type lectin like receptors (CLRs), NOD-like receptors (NLRs), and RIG-I-like receptors (RLRs), which activate downstream signaling pathways. Following bacterial recognition, the first responders of the innate immune system, including neutrophils, macrophages, and dendritic cells, eradicate the bacteria through phagocytic and inflammatory reaction. This review provides current understanding of the interaction between the innate arm of host immunity and , by summarizing recognition by PRRs, and the subsequent signaling pathway activation in host innate immune cells.
是与人类共存了数个世纪的最成功的胃部病原体之一。它通过宿主免疫系统中的人类模式识别受体（PRRs）被识别，如 Toll 样受体（TLRs）、C 型凝集素样受体（CLRs）、NOD 样受体（NLRs）和 RIG-I 样受体（RLRs），这些受体激活下游信号通路。在细菌识别之后，先天免疫系统的第一反应者，包括中性粒细胞、巨噬细胞和树突状细胞，通过吞噬和炎症反应来消灭细菌。这篇综述通过总结 PRRs 对 的识别，以及宿主先天免疫细胞中随后的信号通路激活，提供了宿主先天免疫与 相互作用的最新理解。
