Hu Te, Baxendale Ian R, Baumann Marcus
Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK.
Molecules. 2016 Jul 14;21(7):918. doi: 10.3390/molecules21070918.
The synthesis of diazonium salts is historically an important transformation extensively utilized in dye manufacture. However the highly reactive nature of the diazonium functionality has additionally led to the development of many new reactions including several carbon-carbon bond forming processes. It is therefore highly desirable to determine optimum conditions for the formation of diazonium compounds utilizing the latest processing tools such as flow chemistry to take advantage of the increased safety and continuous manufacturing capabilities. Herein we report a series of flow-based procedures to prepare diazonium salts for subsequent in-situ consumption.
重氮盐的合成在历史上是染料制造中广泛应用的重要转化反应。然而，重氮官能团的高反应活性还催生了许多新反应，包括几种碳-碳键形成过程。因此，利用诸如流动化学等最新加工工具来确定形成重氮化合物的最佳条件，以利用其更高的安全性和连续制造能力，是非常有必要的。在此，我们报告了一系列基于流动的方法，用于制备重氮盐以供后续原位消耗。
