England J M, Panella M J, Ewert D L, Halpern M S
Department of Pathology and Laboratory Medicine, Medical College of Pennsylvania, Philadelphia 19129.
Virology. 1991 Jun;182(2):423-9. doi: 10.1016/0042-6822(91)90583-w.
The presence of peritoneum-based, cytokeratin-positive tumor cells, as detected under conditions of intravenous inoculation of chickens with a v-src-positive DNA fragment, raised the possibility that such DNA may be inductive for diffuse mesothelioma. To investigate this possibility, chickens were inoculated intraperitoneally with v-src DNA, and the resultant peritoneum-based tumor tissue was subjected to histopathological analysis. On the basis of (i) morphology, (ii) immunohistochemistry/histochemistry, and (iii) ultrastructure, we concluded that this tissue represents a diffuse mesothelioma.
在用v-src阳性DNA片段静脉接种鸡的情况下，检测到存在基于腹膜的、细胞角蛋白阳性的肿瘤细胞，这增加了这种DNA可能诱发弥漫性间皮瘤的可能性。为了研究这种可能性，给鸡腹腔内接种v-src DNA，并对由此产生的基于腹膜的肿瘤组织进行组织病理学分析。基于（i）形态学、（ii）免疫组织化学/组织化学和（iii）超微结构，我们得出结论，该组织代表弥漫性间皮瘤。
