Overweg N I, Schiff J D
Eur J Pharmacol. 1978 Jan 15;47(2):231-3. doi: 10.1016/0014-2999(78)90395-3.
The relaxation of depolarized ideal and uterine smooth muscle by isoproterenol was compared with that brought about by dibutyryl-cAMP and by other agents which increase cytoplasmic cAMP. Qualitative differences observed between the time courses of the relaxations imply the existence of a rapid beta-adrenergic mechanism independent of cAMP as well as a slower cAMP-dependent relaxation. This dual process model for beta-adrenergic inhibition of smooth muscle is consistent with seemingly opposing published reports.
将异丙肾上腺素使去极化的理想平滑肌和子宫平滑肌松弛的作用，与二丁酰环磷腺苷及其他能增加细胞质中环磷腺苷的药物所引起的松弛作用进行了比较。在松弛的时间进程中观察到的定性差异表明，存在一种独立于环磷腺苷的快速β-肾上腺素能机制以及一种较慢的环磷腺苷依赖性松弛。这种β-肾上腺素能对平滑肌抑制的双重过程模型与已发表的看似相互矛盾的报告是一致的。
