Haswell-Elkins M R, Sithithaworn P, Mairiang E, Elkins D B, Wongratanacheewin S, Kaewkes S, Mairiang P
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Thailand.
Clin Exp Immunol. 1991 May;84(2):213-8. doi: 10.1111/j.1365-2249.1991.tb08151.x.
Opisthorchis viverrini infection is associated with human hepatobiliary disease and cholangiocarcinoma, but the role of the immune response in the pathogenesis of infection is unclear. Here ultrasonography was used to examine the biliary tracts of residents from an endemic community. Delayed-type hypersensitivity responses to unrelated antigens, and fluke-specific IgG and IgA levels in serum of this group were also examined. Relationships between immunological parameters, intensity of infection and radiologically measured variables are reported. Immune responsiveness to unrelated antigens did not vary with intensity of parasite infection or disease status. Of all the variables, IgG levels were most markedly elevated in disease cases compared with normal subjects and were closely associated with gall bladder size and dysfunction. This is consistent with the hypothesis that an immunopathologic mechanism is involved in opisthorchiasis and suggests that antibody levels may be useful in screening populations for fluke-associated hepatobiliary disease.
华支睾吸虫感染与人类肝胆疾病及胆管癌相关，但免疫反应在感染发病机制中的作用尚不清楚。在此，超声检查被用于检测来自一个地方性流行社区居民的胆道。还检测了该组人群对无关抗原的迟发型超敏反应以及血清中吸虫特异性IgG和IgA水平。报告了免疫参数、感染强度与放射学测量变量之间的关系。对无关抗原的免疫反应性并不随寄生虫感染强度或疾病状态而变化。在所有变量中，与正常受试者相比，疾病患者的IgG水平升高最为明显，且与胆囊大小及功能障碍密切相关。这与华支睾吸虫病涉及免疫病理机制的假说一致，并表明抗体水平可能有助于筛查与吸虫相关的肝胆疾病人群。
