Pascual-Leone A, Gates J R, Dhuna A
Department of Neurology, University of Minnesota, Minneapolis.
Neurology. 1991 May;41(5):697-702. doi: 10.1212/wnl.41.5.697.
Six adult epileptic patients underwent rapid-rate transcranial magnetic stimulation (rTMS) at stimulation rates of up to 25 Hz with an 11-cm water-cooled round coil held flat on the scalp, centered over 15 different positions on each side of the scalp. The trains of stimuli were for 10 seconds while the patients counted aloud. rTMS centered over D5 or D7 induced reproducible speech arrest in all patients and counting errors in three when applied at lower intensities. There were no such speech disturbances by rTMS centered over the different positions on the right side. Intracarotid amobarbital test (IAT) demonstrated left hemispheric language dominance in all patients. Lateralization of speech arrest induced by rTMS correlated with the IAT results and may be helpful for noninvasive determination of hemispheric language dominance.
六名成年癫痫患者接受了快速率经颅磁刺激（rTMS），刺激频率高达25Hz，使用一个11厘米水冷圆形线圈平放在头皮上，以头皮每侧15个不同位置为中心。刺激序列持续10秒，同时患者大声计数。以D5或D7为中心的rTMS在所有患者中均诱发了可重复的言语停顿，在较低强度应用时，三名患者出现计数错误。以右侧不同位置为中心的rTMS未出现此类言语障碍。颈动脉内阿米妥试验（IAT）表明所有患者左侧半球为语言优势半球。rTMS诱发的言语停顿的定位与IAT结果相关，可能有助于非侵入性确定半球语言优势。
