Cheng Jinling, Lin Zhanxiang, Liu Zicai, Han Dongmiao
Department of Rehabilitation Therapy Teaching and Research, Gannan Healthcare Vocational College, Ganzhou, Jiangxi, China.
Department of Rehabilitation Medicine, Shaoguan First People's Hospital, Shaoguan, Guangdong, China.
Front Neurol. 2025 Aug 21;16:1539008. doi: 10.3389/fneur.2025.1539008. eCollection 2025.
Magnetic seizure therapy (MST) is an innovative neurostimulation technique. While MST shares similarities with other neuromodulation techniques, such as electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS), most research has predominantly focused on its efficacy. However, there is a notable scarcity of studies addressing MST's safety. Therefore, the primary aim of this review is to synthesize the available safety data, contributing to a more balanced understanding of this promising treatment modality.
Eight databases (PubMed, Embase, Cochrane Library, Web of Science, CNKI, CBM, VIP, and Wanfang Data) were searched up to August 2024. The evaluation process was strictly adhered to by the Cochrane Risk of Bias assessment tool and RevMan 5.4.
Of the 507 potential studies identified, after excluding duplicate studies, we reviewed the titles and abstracts of 217 studies, 149 of which were excluded. The full text of 68 studies was obtained and assessed against the inclusion and exclusion criteria, with 19 studies meeting the inclusion criteria. The therapeutic device and treatment parameters for MST are still being investigated, and the mechanism of MST is unclear, but there is almost consistent agreement on the efficacy and safety of MST.
This study is the first systematic review of the safety of MST, and the findings suggest that MST can be used as an alternative treatment for certain psychiatric disorders with few side effects. Therefore, larger samples and more randomized controlled double-blind trials are needed in the future better to examine the clinical efficacy and safety of MST.
磁休克疗法（MST）是一种创新的神经刺激技术。虽然MST与其他神经调节技术有相似之处，如电休克疗法（ECT）和经颅磁刺激（TMS），但大多数研究主要集中在其疗效上。然而，关于MST安全性的研究明显匮乏。因此，本综述的主要目的是综合现有的安全性数据，以更全面地了解这种有前景的治疗方式。
检索了截至2024年8月的八个数据库（PubMed、Embase、Cochrane图书馆、Web of Science、中国知网、中国生物医学文献数据库、维普资讯网和万方数据）。评估过程严格遵循Cochrane偏倚风险评估工具和RevMan 5.4。
在识别出的507项潜在研究中，排除重复研究后，我们审查了217项研究的标题和摘要，其中149项被排除。获取了68项研究的全文，并根据纳入和排除标准进行评估，19项研究符合纳入标准。MST的治疗设备和治疗参数仍在研究中，其机制尚不清楚，但对于MST的疗效和安全性几乎有一致的共识。
本研究是对MST安全性的首次系统综述，研究结果表明MST可作为某些精神疾病的替代治疗方法，副作用较少。因此，未来需要更大的样本量和更多的随机对照双盲试验，以更好地检验MST的临床疗效和安全性。
