泊松参数加权和的置信区间。
Confidence intervals for weighted sums of Poisson parameters.
作者信息
Dobson A J, Kuulasmaa K, Eberle E, Scherer J
机构信息
Department of Statistics, University of Newcastle, New South Wales, Australia.
出版信息
Stat Med. 1991 Mar;10(3):457-62. doi: 10.1002/sim.4780100317.
Directly standardized mortality rates are examples of weighted sums of Poisson rate parameters. If the numbers of events are large then normal approximations can be used to calculate confidence intervals, but these are inadequate if the numbers are small. We present a method for obtaining approximate confidence limits for the weighted sum of Poisson parameters as linear functions of the confidence limits for a single Poisson parameter, the unweighted sum. The location and length of the proposed interval depend on the method used to obtain confidence limits for the single parameter. Therefore several methods for obtaining confidence intervals for a single Poisson parameter are compared. For single parameters and for weighted sums of parameters, simulation suggests that the coverage of the proposed intervals is close to the nominal confidence levels. The method is illustrated using data on rates of myocardial infarction obtained as part of the WHO MONICA Project in Augsburg, Federal Republic of Germany.
直接标准化死亡率是泊松率参数加权和的示例。如果事件数量很大,那么可以使用正态近似来计算置信区间,但如果数量较小则这些方法并不适用。我们提出了一种方法,可将泊松参数加权和的近似置信限作为单个泊松参数(未加权和)置信限的线性函数来获得。所提出区间的位置和长度取决于用于获得单个参数置信限的方法。因此,比较了几种获得单个泊松参数置信区间的方法。对于单个参数以及参数的加权和,模拟表明所提出区间的覆盖率接近名义置信水平。使用作为德国联邦共和国奥格斯堡世界卫生组织MONICA项目一部分获得的心肌梗死发病率数据对该方法进行了说明。