Johansson B L, Freyschuss U
Department of Clinical Physiology, Karolinska Institute, Huddinge University Hospital, Sweden.
Acta Paediatr Scand. 1991 Jan;80(1):66-74. doi: 10.1111/j.1651-2227.1991.tb11732.x.
The effects of procedures which stimulate sympathetic activity, viz. mental stress induced by a colour-word conflict test (CWT) for 20 min, and orthostasis (ORT) for 8 min were studied in 8 young (16-20 yr) insulin-dependent diabetes mellitus (IDDM) patients and 9 age and sex-matched healthy controls. The IDDM patients showed no signs of neuropathy or retinopathy and their mean HbA1c value was 8.4 +/- 0.6% (normal value less than 5.0%). Blood pressure and heart rate increased significantly during CWT and ORT in both groups. The changes in systolic blood pressure and heart rate were comparable in both groups during CWT; the IDDM group showed a higher (p less than 0.05) heart rate after 8 min of orthostasis, however. CWT and ORT elicited equivalent increases in noradrenaline in venous plasma in both groups (p less than 0.05), but the IDDM patients had 50% lower values (p less than 0.01) at rest, during CWT and at rest after CWT than controls. CWT and ORT evoked equivalent plasma adrenaline increases in both groups. The lipolysis marker, plasma glycerol, was about 40% lower (p less than 0.05) in the IDDM group before and after CWT. Yet, mental stress evoked equivalent increases in glycerol levels (p less than 0.01) in both groups. These findings indicate that sympathetic activity in the young diabetic patients without signs of neuropathy may be blunted.
对8名年轻（16 - 20岁）的胰岛素依赖型糖尿病（IDDM）患者和9名年龄及性别匹配的健康对照者，研究了刺激交感神经活动的程序的影响，即通过颜色 - 单词冲突测试（CWT）诱导20分钟的精神压力以及8分钟的直立位（ORT）。IDDM患者无神经病变或视网膜病变迹象，其平均糖化血红蛋白（HbA1c）值为8.4±0.6%（正常值小于5.0%）。两组在CWT和ORT期间血压和心率均显著升高。CWT期间两组收缩压和心率的变化相当；然而，直立位8分钟后，IDDM组心率更高（P<0.05）。两组CWT和ORT均使静脉血浆中去甲肾上腺素等量增加（P<0.05），但IDDM患者在静息时、CWT期间及CWT后静息时的值比对照组低50%（P<0.01）。两组CWT和ORT均使血浆肾上腺素等量增加。脂解标志物血浆甘油在IDDM组CWT前后约低40%（P<0.05）。然而，精神压力使两组甘油水平等量增加（P<0.01）。这些发现表明，无神经病变迹象的年轻糖尿病患者的交感神经活动可能减弱。
