Colón L E
Ophthalmology Service, Fitzsimons Army Medical Center, Aurora, Colorado.
Ann Ophthalmol. 1991 Feb;23(2):63-5.
A large nosocomial, community-acquired outbreak of keratoconjunctivitis due to adenovirus type 8 at a large military teaching hospital is described. One hundred thirty-two cases were identified with initial case confirmation by viral isolation and subsequent case confirmation based on clinical findings. Infection usually presented as a severe keratoconjunctivitis with 35% of infected patients developing subepithelial corneal infiltrates. Most infections were acquired by hand-to-eye contact or by tonometry while visiting the military eye service for other ophthalmologic reasons. Intrafamilial transmission of the virus occurred in 22% of cases with rare disease spread outside the family or hospital environments. The peak incidence occurred from April to August 1986 but was not confirmed by viral isolation until May 1986 when appropriate control measures were instituted. The delay in application of appropriate control measures was a major factor accounting for both the prolonged duration and epidemic nature of this kerato-conjunctivitis outbreak.
本文描述了一家大型军队教学医院因8型腺病毒引起的大规模医院内获得性、社区获得性角结膜炎暴发。通过病毒分离进行初始病例确诊，并根据临床发现进行后续病例确诊，共识别出132例病例。感染通常表现为严重的角结膜炎，35%的感染患者出现角膜上皮下浸润。大多数感染是通过手眼接触或因其他眼科原因前往军队眼科就诊时眼压测量而获得的。22%的病例发生了病毒的家庭内传播，在家庭或医院环境之外很少有疾病传播。发病高峰出现在1986年4月至8月，但直到1986年5月采取适当控制措施后才通过病毒分离得到确认。延迟采取适当的控制措施是导致这次角结膜炎暴发持续时间延长和具有流行性的主要因素。
