Matsuno M, Murakami G, Adachi Y, Adachi Y, Kayahara M, Okada T, Arakawa R, Kawai K, Igarashi T
Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Arerugi. 1991 Jan;40(1):51-9.
We collected airborne particles in the air using a high-volume air sampler, and measured chironomid allergen in the air-filter extract by use of RAST inhibition assay. The results obtained were as follows: 1) The assay revealed the presence of chironomid allergen in the air varying from 6.8 to less than 0.3 ng/m3. 2) In Toyama, seasonal fluctuations of airborne chironomid allergen demonstrated some large peaks in summer (June to August), and showed a tendency to decrease in winter. 3) There were significant correlations between airborne chironomid allergen and dry weight of chironomid midges, collected by using light traps, in all period of a week just before, 1 to 2 weeks before, 2 to 3 weeks before, or 3 to 4 weeks before air sampling. There were not significant correlations between airborne chironomid allergen and weathers (temperature, wind speed and precipitation) during or just before air sampling. 4) In Toyama, the frequency of asthma attacks in the asthmatic children with positive C.p. RAST was much increased in summer compared with that of the negative, in which the amount of airborne chironomid allergen was increased. These results show that there is large amount of chironomid allergen in the air from spring to autumn, especially large in summer, and it is related for some asthmatics to the increase of the frequency of asthma attack.
我们使用大容量空气采样器收集空气中的悬浮颗粒，并通过放射性变应原吸附抑制试验（RAST抑制试验）测量空气过滤器提取物中的摇蚊过敏原。获得的结果如下：1）该试验显示空气中存在摇蚊过敏原，含量在6.8至低于0.3 ng/m³之间变化。2）在富山，空气中摇蚊过敏原的季节性波动在夏季（6月至8月）出现一些大的峰值，冬季呈下降趋势。3）在空气采样前一周内、前1至2周、前2至3周或前3至4周的所有时间段，空气中摇蚊过敏原与用诱虫灯收集的摇蚊干重之间存在显著相关性。在空气采样期间或采样前，空气中摇蚊过敏原与天气（温度、风速和降水量）之间无显著相关性。4）在富山，夏季CP RAST呈阳性的哮喘儿童哮喘发作频率比阴性儿童大幅增加，此时空气中摇蚊过敏原含量增加。这些结果表明，从春季到秋季空气中存在大量摇蚊过敏原，夏季尤其多，并且这与一些哮喘患者哮喘发作频率增加有关。
