Thom D H, Wang S P, Grayston J T, Siscovick D S, Stewart D K, Kronmal R A, Weiss N S
Department of Epidemiology, University of Washington, Seattle 98195.
Arterioscler Thromb. 1991 May-Jun;11(3):547-51. doi: 10.1161/01.atv.11.3.547.
A recent case-control study from Finland reported a strong association between high antibody titers to Chlamydia pneumoniae, strain TWAR, and both chronic coronary heart disease and acute myocardial infarction. The current case-control study investigated the relation between C. pneumoniae immunoglobulin G antibody titers and angiographically diagnosed coronary artery disease. Cases (n = 461) were angiography patients with at least one coronary artery lesion occupying at least 50% of the luminal diameter. Controls (n = 95) were angiography patients with no demonstrable coronary artery disease. After standardization for age and gender, the geometric mean antibody titer was higher for cases than for controls (30.0 versus 24.0, p = 0.04). The estimated risk of coronary artery disease, adjusted for age and gender, was greater among subjects with high (greater than or equal to 1:64) antibody titers than among subjects with low (less than or equal to 1:8) antibody titers (relative risk, 2.0; 95% confidence interval, 1.0-4.0). The risk associated with a high antibody titer was particularly great for coronary artery disease with five or more lesions (relative risk, 2.8; 95% confidence interval, 1.2-7.0). The results of this cross-sectional study support an association between infection with C. pneumoniae and coronary artery disease.
芬兰最近的一项病例对照研究报告称，肺炎衣原体TWAR株的高抗体滴度与慢性冠心病和急性心肌梗死之间存在密切关联。当前的这项病例对照研究调查了肺炎衣原体免疫球蛋白G抗体滴度与经血管造影诊断的冠状动脉疾病之间的关系。病例组（n = 461）为至少有一处冠状动脉病变且管腔直径至少被占据50%的血管造影患者。对照组（n = 95）为无明显冠状动脉疾病的血管造影患者。在对年龄和性别进行标准化后，病例组的几何平均抗体滴度高于对照组（30.0对24.0，p = 0.04）。经年龄和性别调整后，抗体滴度高（大于或等于1:64）的受试者患冠状动脉疾病的估计风险高于抗体滴度低（小于或等于1:8）的受试者（相对风险为2.0；95%置信区间为1.0 - 4.0）。对于有五个或更多病变的冠状动脉疾病，高抗体滴度相关的风险尤其大（相对风险为2.8；95%置信区间为1.2 - 7.0）。这项横断面研究的结果支持肺炎衣原体感染与冠状动脉疾病之间存在关联。
