Jangjoo Ali, Bahar Mostafa Mehrabi, Soltani Ehsan
Department of General Surgery, MUMS Research Center for Surgery, Mashhad University of Medical Sciences, Imam Reza University Hospital, Mashhad, Iran.
J Opioid Manag. 2010 Jan-Feb;6(1):63-6. doi: 10.5055/jom.2010.0006.
One of the major challenges faced by the treatment planning teams is how to manage postoperative pain. Previous studies agreed upon the effects of preoperative administration of nonsteroidal anti-inflammatory drugs on postoperative pain, but all have focused on patients with surgical noninflammatory diseases (ie, inguinal hernia or breast biopsy). The aim of this study was to evaluate the effects of rectal indomethacin on reducing postoperative pain in patients with acute appendicitis.
It is a simple randomized, clinical trial including 200 patients with acute appendicitis who were divided into two groups (A1 and A2). The case group (A1) received 100 mg rectal indomethacin during 2 hours before the operation. Pain intensity was assessed in all patients using a visual analog scale (VAS). Similarly, total dosage of meperidine analgesic medication and postoperative time to use of rescue analgesia were evaluated.
Patients who received preoperative rectal indomethacin (A1) showed a significant reduction in the VAS score. Also, a reduction in total dose of meperidine and longer time to use of rescue analgesic medication were observed in A1 group.
Preoperative administration of rectal indomethacin in acute appendicitis reduces postoperative pain.
治疗计划团队面临的主要挑战之一是如何管理术后疼痛。先前的研究一致认为术前给予非甾体类抗炎药对术后疼痛有影响，但所有研究都集中在患有外科非炎症性疾病（如腹股沟疝或乳腺活检）的患者身上。本研究的目的是评估直肠给予吲哚美辛对减轻急性阑尾炎患者术后疼痛的效果。
这是一项简单随机临床试验，纳入200例急性阑尾炎患者，分为两组（A1组和A2组）。病例组（A1组）在手术前2小时直肠给予100mg吲哚美辛。使用视觉模拟量表（VAS）评估所有患者的疼痛强度。同样，评估哌替啶镇痛药物的总剂量和术后使用急救镇痛的时间。
术前接受直肠吲哚美辛治疗的患者（A1组）VAS评分显著降低。此外A1组哌替啶总剂量减少，使用急救镇痛药物的时间延长。
急性阑尾炎患者术前直肠给予吲哚美辛可减轻术后疼痛。
