Crocker S, Paech M
Department of Anaesthesia, King Edward Memorial Hospital for Women, Perth, Western Australia.
Anaesth Intensive Care. 1992 Aug;20(3):337-40. doi: 10.1177/0310057X9202000311.
A randomised, double-blind, placebo-controlled study was conducted among 56 day-case patients to determine the effect of the preoperative administration of rectal indomethacin on postoperative pain and opioid requirements after laparoscopic sterilisation. Outcome in women receiving indomethacin did not differ significantly from the placebo group, but there was a trend to lower subjective pain scores, reduction in early postoperative pain assessed objectively and lower parenteral pethidine requirements in the first three hours postoperatively. Indomethacin did not appear either to cause side-effects or to significantly reduce morbidity from the other postoperative sequelae of laparoscopy. Despite evidence for postoperative analgesic effect, the clinical benefits of premedication with rectal indomethacin were minor.
一项随机、双盲、安慰剂对照研究在56例日间手术患者中进行，以确定术前直肠给予吲哚美辛对腹腔镜绝育术后疼痛及阿片类药物需求的影响。接受吲哚美辛治疗的女性患者的结果与安慰剂组无显著差异，但存在主观疼痛评分降低、术后早期客观评估的疼痛减轻以及术后前三小时胃肠外哌替啶需求量降低的趋势。吲哚美辛似乎既未引起副作用，也未显著降低腹腔镜检查其他术后后遗症的发病率。尽管有证据表明其具有术后镇痛作用，但术前直肠给予吲哚美辛的临床益处较小。
