Murrell G C, Leake T, Hughes P J
Freemasons Hospital Day Procedure Centre, Melbourne, Victoria, Australia.
Anaesth Intensive Care. 1996 Apr;24(2):237-40. doi: 10.1177/0310057X9602400216.
The analgesia provided in the postoperative period by three regimens commonly used in our private anaesthetic practice were compared in a double-blind study of one hundred and thirty-seven women presenting for day-case laparoscopic procedures. After random allocation into three groups, all patients were similarly anaesthetized and then received both a rectal suppository and an IM injection. Group P received two placebos, Group I had an indomethacin suppository 100 mg and Group K an IM injection of ketorolac 30 mg. The trial showed a statistically significant reduction in pain at 180 minutes postoperatively in the group receiving ketorolac (visual analog pain score of 13.8 v 21.7). The parenterally administered ketorolac may be a useful analgesic supplement in these patients. However the trial was aborted following the appearance in the literature of case reports of postoperative renal failure. Further investigation of the efficacy and side-effect profile of reduced doses may be warranted.
在一项针对137名接受日间腹腔镜手术的女性的双盲研究中，比较了我们私人麻醉实践中常用的三种方案在术后提供的镇痛效果。随机分为三组后，所有患者均接受相似的麻醉，然后接受直肠栓剂和肌肉注射。P组接受两种安慰剂，I组接受100毫克吲哚美辛栓剂，K组接受30毫克酮咯酸肌肉注射。试验表明，接受酮咯酸的组在术后180分钟时疼痛有统计学意义的减轻（视觉模拟疼痛评分为13.8对21.7）。胃肠外给药的酮咯酸可能是这些患者有用的镇痛补充剂。然而，在文献中出现术后肾衰竭病例报告后，该试验中止。可能有必要进一步研究降低剂量的疗效和副作用情况。
