铜催化的伯苄位 C-H 键与伯、仲磺酰胺的胺化反应。
Copper-catalyzed amination of primary benzylic C-H bonds with primary and secondary sulfonamides.
机构信息
Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Quebec H9H 3L1, Canada.
出版信息
J Org Chem. 2010 Apr 16;75(8):2726-9. doi: 10.1021/jo100197r.
PMID:20297848
Abstract
A room-temperature, copper-catalyzed amination of primary benzylic C-H bonds with primary and secondary sulfonamides is described. The reaction is applicable to the coupling of a range of primary and secondary benzylic hydrocarbons with a diverse set of sulfonamides and is tolerant of substitution on both coupling partners. Factors which influence the selectivity of C-H functionalization between primary and secondary sites are examined.
摘要
描述了一种在室温下、铜催化的伯苄基 C-H 键与伯和仲磺酰胺的胺化反应。该反应适用于一系列伯和仲苄基烃与各种磺酰胺的偶联，并且对两种偶联物上的取代基都具有耐受性。还研究了影响伯和仲位点间 C-H 官能化选择性的因素。
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