一种新的杂环 C-H 键胺化试剂：铜催化室温下氯代胺与唑类化合物的直接胺化反应。
A new entry of amination reagents for heteroaromatic C-H bonds: copper-catalyzed direct amination of azoles with chloroamines at room temperature.
机构信息
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
出版信息
J Am Chem Soc. 2010 May 26;132(20):6900-1. doi: 10.1021/ja101939r.
PMID:20438076
Abstract
Chloroamine serves as an efficient amination reagent to the heteroaromatic C-H bond of azole under copper catalysis even at room temperature. This catalysis enables a rapid and concise construction of aminoazoles of great interest in biological and medicinal chemistry.
摘要
氯胺在铜催化下可作为一种高效的芳杂环 C-H 键胺化试剂，甚至在室温下也能进行。这种催化作用可以快速简洁地构建在生物和药物化学中具有重要意义的氨基唑类化合物。
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