Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea.
Respir Med. 2010 Aug;104(8):1197-203. doi: 10.1016/j.rmed.2010.02.014. Epub 2010 Mar 17.
It has been observed that restrictive pulmonary function is associated with obesity and C-reactive protein (CRP), an indicator for systemic inflammation. However, the interrelationship among body composition, CRP, and restrictive pulmonary function has been poorly understood. This study focused on the combined effects of body composition and CRP on restrictive pulmonary function.
We performed a cross-sectional study to examine the association of body composition and CRP with restrictive pulmonary function in 12,787 subjects (7083 men, 5704 women; ages 20-75 yr). We evaluated body composition and CRP as a categorical variable (non-obesity, percentage body fat <or=75 percentile; obesity, percentage body fat >75 percentile; low-inflammation, CRP <or=75 percentile; high-inflammation, CRP >75 percentile) and constructed 4 groups, which were non-overlapping (reference, inflammatory, obese, obese and inflammatory). The odds ratios (ORs) and 95% confidence intervals (CIs) for restrictive pulmonary function were calculated across all 4 groups.
The adjusted ORs (95% CIs) for restrictive pulmonary function according to the 4 groups were 1.00(reference), 1.19(0.93-1.52), 2.01(1.53-2.64) and 3.51(2.60-4.74) in men and 1.00 (reference), 1.26 (0.96-1.69), 1.02 (0.58-1.81), and 3.32 (2.09-5.27) in women after adjusting for confounding variables. Interaction was found between the body fat percentage and CRP in women only (P < 0.05).
In summary, the coexistence of high fat accumulation and systemic subclinical inflammation is associated with restrictive pulmonary function.
已经观察到限制性肺功能与肥胖和 C 反应蛋白（CRP）有关，CRP 是全身炎症的一个指标。然而，身体成分、CRP 和限制性肺功能之间的相互关系还没有被很好地理解。本研究侧重于身体成分和 CRP 对限制性肺功能的综合影响。
我们进行了一项横断面研究，以检查 12787 名受试者（7083 名男性，5704 名女性；年龄 20-75 岁）的身体成分和 CRP 与限制性肺功能的关系。我们将身体成分和 CRP 作为一个分类变量进行评估（非肥胖，体脂百分比<=75 百分位；肥胖，体脂百分比>75 百分位；低炎症，CRP<=75 百分位；高炎症，CRP>75 百分位），并构建了 4 个不重叠的组（参考组、炎症组、肥胖组、肥胖和炎症组）。在所有 4 个组中计算了限制性肺功能的比值比（OR）和 95%置信区间（CI）。
在男性中，根据 4 个组，调整后的限制性肺功能 OR（95%CI）分别为 1.00（参考组）、1.19（0.93-1.52）、2.01（1.53-2.64）和 3.51（2.60-4.74），在女性中，调整混杂因素后，分别为 1.00（参考组）、1.26（0.96-1.69）、1.02（0.58-1.81）和 3.32（2.09-5.27）。仅在女性中发现体脂百分比和 CRP 之间存在交互作用（P<0.05）。
总之，高脂肪堆积和全身亚临床炎症的共存与限制性肺功能有关。
