Lee Do Y, Nam Seung M
Department of Physical Therapy, Daegu University, Gyeongsan-si 38453, South Korea.
World J Diabetes. 2020 Oct 15;11(10):425-434. doi: 10.4239/wjd.v11.i10.425.
Diabetes is a progressive disease that increases glucose levels in the blood. While studies have shown that patients with pulmonary disease (both obstructive and restrictive pulmonary disease) have a higher prevalence of type 2 diabetes mellitus (T2DM), there have been more studies on restrictive patterns than chronic obstructive pulmonary disease.
To assess whether restrictive and obstructive pulmonary diseases are associated with T2DM in Koreans.
For our analysis, we used data from the Korea National Health and Nutrition Examination Survey. A total of 2830 subjects were included in this study. Spirometry results were categorized into three patterns: Normal, restrictive pulmonary disease (RPD), and obstructive pulmonary disease (OPD).
The factors used as diabetic indicators (. homeostatic model assessment of insulin resistance, homeostatic model assessment of beta-cell function, glycated hemoglobin, and fasting insulin) were among the highest in RPD but not in OPD. Based on multivariate logistic regression analysis, subjects with RPD were found with an increased odds ratio [OR: 1.907, 95% confidence interval (CI): 1.110-3.277] for T2DM compared with subjects with normal pulmonary function, whereas in patients with OPD, the OR had not increased. Model 4, which adjusted for the variables that could affect diabetes and pulmonary disease, showed a significant increase in the T2DM OR to RPD (OR: 2.025, 95%CI: 1.264-3.244). On the other hand, no statistically significant difference was shown in OPD (OR: 0.982, 95%CI: 0.634-1.519).
RPD, not OPD, is highly associated with T2DM regardless of the risk factors of various T2DMs that can be confounds.
糖尿病是一种使血液中葡萄糖水平升高的进行性疾病。虽然研究表明，患有肺部疾病（包括阻塞性和限制性肺部疾病）的患者患2型糖尿病（T2DM）的患病率更高，但关于限制性模式的研究比对慢性阻塞性肺疾病的研究更多。
评估在韩国人中，限制性和阻塞性肺部疾病是否与T2DM相关。
为进行分析，我们使用了韩国国家健康与营养检查调查的数据。本研究共纳入2830名受试者。肺功能测定结果分为三种模式：正常、限制性肺部疾病（RPD）和阻塞性肺部疾病（OPD）。
用作糖尿病指标的因素（胰岛素抵抗的稳态模型评估、β细胞功能的稳态模型评估、糖化血红蛋白和空腹胰岛素）在RPD组中处于最高水平，但在OPD组中并非如此。基于多因素逻辑回归分析，与肺功能正常的受试者相比，RPD受试者患T2DM的比值比[OR：1.907，95%置信区间（CI）：1.110 - 3.277]升高，而在OPD患者中，OR并未升高。对可能影响糖尿病和肺部疾病的变量进行校正的模型4显示，RPD的T2DM OR显著升高（OR：2.025，95%CI：1.264 - 3.244）。另一方面，OPD组未显示出统计学上的显著差异（OR：0.982，95%CI：0.634 - 1.519）。
无论各种可能作为混杂因素的T2DM风险因素如何，RPD而非OPD与T2DM高度相关。
