Plant Physiol Biochem. 2010 May;48(5):289-91. doi: 10.1016/j.plaphy.2010.02.011. Epub 2010 Feb 21.
The concepts of antioxidants and redox regulation are reconsidered in the light of recent findings, and some new future challenges for redox biology are outlined. It is suggested that antioxidants, thioredoxin-mediated redox regulation, and signal transduction mediated by reactive oxygen and nitrogen species, are all part of the same broad mechanism. The integration of different redox inputs, by affecting reversible thiol-disulfide dynamics in a set of target proteins, could result in the regulation of key processes such as proteolysis, gene expression and the functioning of selected metabolic pathways. Most interestingly, redox regulation is not just based on a binary "yes or no" response, and is therefore a convenient way to achieve graded control over the continuum of environmental variables.
在最近的研究发现的基础上，重新考虑了抗氧化剂和氧化还原调节的概念，并概述了氧化还原生物学的一些新的未来挑战。有人认为，抗氧化剂、硫氧还蛋白介导的氧化还原调节以及活性氧和氮物种介导的信号转导，都是同一广泛机制的一部分。不同的氧化还原输入的整合，通过影响一组靶蛋白中可逆的巯基-二硫键动力学，可以导致关键过程的调节，如蛋白水解、基因表达和选定代谢途径的功能。最有趣的是，氧化还原调节不仅仅基于二元的“是或否”反应，因此是一种方便的方法，可以对环境变量的连续统进行分级控制。
